Results 221 to 230 of about 20,294,267 (243)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

d-Dimer With the Aortic Dissection Detection Risk Score May Improve Patient Selection for Acute Aortic Syndrome Diagnostic Imaging. [PDF]

Emerg Med Australas
Bhat S, Bhat S, Schreve F, Bergin CJ, Jones PG, Waqanivavalagi SWFR.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Association of Vitamin D Status With Mortality and Microbial Spectrum in Late-Onset Neonatal Sepsis: A Comparative Observational Study. [PDF]

Cureus
Yadav A, Anand P, Gera R, Dawson L.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function. [PDF]

Aging Cell
Cai JR, Zhang J, Ning YX, Zhang J, Xu TC, Liu MC, Wang KX, Chen HS.   +7 more
europepmc   +1 more source

Natural monosaccharide-based piezoelectric supramolecular materials for energy harvesting and information transmission. [PDF]

Chem Sci
Chen S, Yang J, Liu S, Huo Y, Cheng X, Li L, Ji W.   +6 more
europepmc   +1 more source

Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the <i>Mecp2-</i>Deficient Mouse Model. [PDF]

Cells
Vyas P, Khoury ES, Sah N, Sharma A, Allende Labastida J, Wilkinson EL, Lac K, Damiba NNL, Fowler A, Liu J, Bedner A, Majer P, Tichý T, Thomas AG, Rais R, Slusher BS, Kannan RM, Kannan S.   +17 more
europepmc   +1 more source