Results 41 to 50 of about 20,294,267 (243)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Aging Cell, 2016 Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven bioinformatics‐based approach, we recently identified pro‐survival pathways in human senescent cells that contribute to their resistance to apoptosis.Yi Zhu, T. Tchkonia, Heike Fuhrmann-Stroissnigg, Haiming Dai, Y. Ling, Michael B. Stout, T. Pirtskhalava, N. Giorgadze, Kurt O. Johnson, Cory B. Giles, J. Wren, L. Niedernhofer, P. Robbins, J. Kirkland +13 moresemanticscholar +1 more sourcePsychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction
The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde +6 morewiley +1 more sourceLittle strings on D n orbifolds
Journal of High Energy Physics, 2017 We explore two classes of 6d N = 1 0 $$ \mathcal{N}=\left(1,0\right) $$ little string theories obtained from type IIA/IIB NS5-branes probing D n singularities.Joonho Kim, Kimyeong Leedoaj +1 more sourcePathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Science, 2018 Caspase-8 is a player in pyroptosis The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes.Pontus Orning, D. Weng, K. Starheim, Dmitry Ratner, Zachary Best, Bettina L. Lee, Alexandria Brooks, S. Xia, Hao Wu, M. Kelliher, S. Berger, P. Gough, J. Bertin, Megan M Proulx, J. Goguen, N. Kayagaki, K. Fitzgerald, E. Lien +17 moresemanticscholar +1 more sourceNutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose
Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard +10 morewiley +1 more sourcePlanck2015 results
Astronomy & Astrophysics, 2016 This paper describes the mapmaking procedure applied to Planck Low Frequency Instrument (LFI) data. The mapmaking step takes as input the calibrated timelines and pointing information.P. Ade, N. Aghanim, M. Arnaud, M. Ashdown, J. Aumont, C. Baccigalupi, A. Banday, R. B. Barreiro, R. Barrena, J. G. Bartlett, N. Bartolo, E. Battaner, R. Battye, K. Benabed, A. Benoit, A. Benoit-Lévy, J. Bernard, M. Bersanelli, P. Bielewicz, I. Bikmaev, H. Böhringer, A. Bonaldi, L. Bonavera, J. R. Bond, J. Borrill, F. Bouchet, M. Bucher, R. Burenin, C. Burigana, R. Butler, E. Calabrese, J. Cardoso, P. Carvalho, A. Catalano, A. Challinor, A. Chamballu, R. Chary, H. Chiang, G. Chon, P. Christensen, D. Clements, S. Colombi, L. Colombo, C. Combet, B. Comis, F. Couchot, A. Coulais, B. Crill, A. Curto, F. Cuttaia, H. Dahle, L. Danese, R. Davies, R. Davis, P. de Bernardis, A. de Rosa, G. De Zotti, J. Delabrouille, F. Désert, C. Dickinson, J. M. Diego, K. Dolag, H. Dole, S. Donzelli, O. Doré, M. Douspis, A. Ducout, X. Dupac, G. Efstathiou, P. Eisenhardt, F. Elsner, T. Ensslin, H. Eriksen, E. Falgarone, J. Fergusson, F. Feroz, A. Ferragamo, F. Finelli, O. Forni, M. Frailis, A. Fraisse, E. Franceschi, A. Frejsel, S. Galeotta, S. Galli, K. Ganga, R. Génova-Santos, M. Giard, Y. Giraud-Héraud, E. Gjerløw, J. González-Nuevo, K. Górski, K. Grainge, S. Gratton, A. Gregorio, A. Gruppuso, J. Gudmundsson, F. Hansen, D. Hanson, D. L. Harrison, A. Hempel, S. Henrot-Versillé, C. Hernández-Monteagudo, D. Herranz, S. Hildebrandt, E. Hivon, M. Hobson, W. Holmes, A. Hornstrup, W. Hovest, K. Huffenberger, G. Hurier, A. Jaffe, T. Jaffe, T. Jin, W. Jones, M. Juvela, E. Keihänen, R. Keskitalo, I. Khamitov, T. Kisner, R. Kneissl, J. Knoche, M. Kunz, H. Kurki-Suonio, G. Lagache, J. Lamarre, A. Lasenby, M. Lattanzi, C. Lawrence, R. Leonardi, J. Lesgourgues, F. Levrier, M. Liguori, P. Lilje, M. Linden-Vørnle, M. López-Caniego, P. Lubin, J. Macías-Pérez, G. Maggio, D. Maino, D. Mak, N. Mandolesi, A. Mangilli, P. Martin, E. Martinez-Gonzalez, S. Masi, S. Matarrese, P. Mazzotta, P. McGehee, S. Mei, A. Melchiorri, J. Melin, L. Mendes, A. Mennella, M. Migliaccio, S. Mitra, M. Miville-Deschênes, A. Moneti, L. Montier, G. Morgante, D. Mortlock, A. Moss, D. Munshi, J. A. Murphy, P. Naselsky, A. Nastasi, F. Nati, P. Natoli, C. Netterfield, H. Nørgaard-Nielsen, F. Noviello, D. Novikov, I. Novikov, M. Olamaie, C. A. Oxborrow, F. Paci, L. Pagano, F. Pajot, D. Paoletti, F. Pasian, G. Patanchon, T. Pearson, O. Perdereau, L. Perotto, Y. Perrott, F. Perrotta, V. Pettorino, F. Piacentini, M. Piat, E. Pierpaoli, D. Pietrobon, S. Plaszczynski, E. Pointecouteau, G. Polenta, G. Pratt, G. Prézeau, S. Prunet, J. Puget, J. Rachen, W. Reach, R. Rebolo, M. Reinecke, M. Remazeilles, C. Renault, A. Renzi, I. Ristorcelli, G. Rocha, C. Rosset, M. Rossetti, G. Roudier, E. Rozo, J. Rubiño-Martín, C. Rumsey, B. Rusholme, E. Rykoff, M. Sandri, D. Santos, R. D. E. Saunders, M. Savelainen, G. Savini, M. Schammel, D. Scott, M. Seiffert, E. Shellard, T. W. Shimwell, L. Spencer, S. Stanford, D. Stern, V. Stolyarov, R. Stompor, A. Streblyanska, R. Sudiwala, R. Sunyaev, D. Sutton, A.-S. Suur-Uski, J. Sygnet, J. Tauber, L. Terenzi, L. Toffolatti, M. Tomasi, D. Tramonte, M. Tristram, M. Tucci, J. Tuovinen, G. Umana, L. Valenziano, J. Valiviita, B. van Tent, P. Vielva, F. Villa, L. Wade, B. Wandelt, I. Wehus, S. White, E. L. Wright, D. Yvon, A. Zacchei, A. Zonca +258 moresemanticscholar +1 more sourceSurvival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background
The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco +56 morewiley +1 more sourceDegree sequence for k-arc strongly connected multiple digraphs
Journal of Inequalities and Applications, 2017 Let D be a digraph on { v 1 , … , v n } $\{v_{1},\ldots, v_{n}\}$ . Then the sequence { ( d + ( v 1 ) , d − ( v 1 ) ) , … , ( d + ( v n ) , d − ( v n ) ) } $\{ (d^{+}(v_{1}), d^{-}(v_{1})), \ldots, (d^{+}(v_{n}), d^{-}(v_{n}))\}$ is called the degree ...Yanmei Hong, Qinghai Liudoaj +1 more sourceHeart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Circulation, 2016 Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; D. Mozaffarian, E. Benjamin, A. Go, D. Arnett, M. Blaha, M. Cushman, Sandeep R. Das, S. D. de Ferranti, J. Despres, H. Fullerton, V. Howard, Mark D. Huffman, C. Isasi, M. Jimenez, S. Judd, B. Kissela, J. Lichtman, L. Lisabeth, Simin Liu, R. Mackey, D. Magid, Darren K Mcguire, E. Mohler, C. Moy, P. Muntner, M. Mussolino, K. Nasir, R. Neumar, G. Nichol, L. Palaniappan, D. Pandey, M. Reeves, C. Rodriguez, W. Rosamond, P. Sorlie, J. Stein, A. Towfighi, T. Turan, S. Virani, D. Woo, R. Yeh, M. B. Turner +41 moresemanticscholar +1 more source