Results 261 to 270 of about 5,871,797 (300)

6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation. [PDF]

Pharmacol Res Perspect
Britto-Júnior J, Godoy PRC, Lima DO, de Souza VB, Schenka AA, Mariano FV, Jacintho FF, Hermawan I, Shimokawa H, Tsutsui M, Chiavegatto S, Antunes E, De Nucci G.   +12 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Diverse biofilm-forming <i>Sphingomonadaceae</i> represent twelve novel species isolated from glaciers on the Tibetan Plateau. [PDF]

Int J Syst Evol Microbiol
Han D, Xin YH, Liu Q.
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Ongoing circulation of emerging tick-borne viruses in Poland, Eastern Europe. [PDF]

PLoS One
Ergunay K, Golubiani G, Kirkitadze G, Reinbold-Wasson DD, Bourke BP, Phelps CA, Kotorashvili A, Kotaria N, Hulseberg CE, Chunashvili T, Sydenstricker A, Shubashishvili A, Musich TA, Linton YM.   +13 more
europepmc   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress. [PDF]

Elife
Malita A, Skakkebaek AH, Kubrak O, Chen X, Koyama T, Connolly EC, Ahrentloev N, Andersen DS, Texada MJ, Halberg K, Rewitz K.   +10 more
europepmc   +1 more source

キャラクター カラ カンジル インショウ ノ ケンキュウ [PDF]

, 2015
Atsushi MUTA, Division of Liberal Arts and Science, Faculty of Arts, Tokyo Polytechnic University, 東京工芸大学芸術学部基礎教育課程, 牟田 淳   +3 more
core   +1 more source