Results 111 to 116 of about 116 (116)

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

Conservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta, Catriona M. Harris, Lori H. Schwacke, Len Thomas, Jason B. Allen, Aaron A. Barleycorn, Marco Casoli, Jonathan Crossman, Laura Aichinger Dias, Laura Engleby, Erin LaBrecque, Jenny A. Litz, Katherine A. McHugh, Patrick J. O. Miller, Michael J. Moore, Theoni Photopoulou, Brian M. Quigley, Cynthia R. Smith, Brandon L. Southall, Todd R. Speakman, Ryan Takeshita, Christina N. Toms, Randall S. Wells, Eric S. Zolman, Peter L. Tyack   +24 more
wiley   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Demonstration of a High‐Resolution Passive Profiler for Characterizing the Distribution of PFAS in Groundwater: A Comparison of Methods in the Field

Groundwater Monitoring &Remediation, EarlyView.
Abstract Characterizing the concentration and mass flux spatial distributions at sites with complex hydrogeologic conditions is critical to evaluate the fate and transport of contaminants, as well as to design effective remediation programs. PFAS (per‐ and polyfluoroalkyl substances)‐contaminated sites are even more complex due to the large number of ...
Morgan Eldridge, Jessica LaFond, Micaela Vavra, Graig Lavorgna, David Lippincott, Paul Hatzinger, Jennifer Guelfo, Todd Anderson, W. Andrew Jackson   +8 more
wiley   +1 more source

In Situ Colloidal Activated Carbon for PFAS Remediation in Groundwater: Principles, Performance Expectations, and Lessons from the First Decade

Groundwater Monitoring &Remediation, EarlyView.
Abstract Injectable colloidal activated carbon (CAC) has been commercially used to remediate per and polyfluoroalkyl substances (PFAS) in groundwater since 2016. The basis of the technology is enhanced PFAS retention within the aquifer from engineered increases in aquifer‐matrix sorptivity (“PFAS enhanced retention”), with re‐equilibration from the ...
Jeremy Birnstingl
wiley   +1 more source