Results 101 to 110 of about 390 (121)
Annals of Neurology, EarlyView.Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas +29 more
wiley +1 more source
Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths
Annals of Neurology, EarlyView.Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian +10 more
wiley +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin +8 more
wiley +1 more source
Phenazine‐Based Synthetic Biology to Signal Between Cells and Electrodes
Biotechnology and Bioengineering, EarlyView.ABSTRACT Bioelectronic systems that enable seamless communication between electronic devices and living systems represent a transformative frontier in biotechnology. Among available methodologies, redox based signaling offers unique advantages due to its ubiquity in biology and compatibility with standard electrochemical equipment, expanding on ...
Eric VanArsdale +8 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Biopharmaceutical manufacturing requires robust analytics and process controls throughout production to insure high yield of quality products. New methodologies for rapidly accessing and integrating data‐rich information from complex dynamic biological environments are of great interest.
Kayla Chun +8 more
wiley +1 more source
Clinical Anatomy, EarlyView.ABSTRACT Understanding how pancreas size and shape change with normal aging is critical for establishing a baseline to detect deviations in type 2 diabetes and other pancreatic disease. We measure pancreas size and shape using morphological measurements from early development through aging (ages 0–90).
Lucas W. Remedios +13 more
wiley +1 more source
Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound
Chemistry – A European Journal, EarlyView.ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske +5 more
wiley +1 more source
Rank‐based estimation of propensity score weights via subclassification
Canadian Journal of Statistics, EarlyView.Abstract Propensity score (PS) weighting estimators are widely used for causal effect estimation and enjoy desirable theoretical properties, such as consistency and potential efficiency under correct model specification. However, their performance can degrade in practice due to sensitivity to PS model misspecification.
Linbo Wang +3 more
wiley +1 more source
Contributions to Plasma Physics, EarlyView.ABSTRACT Advances in ultra‐intense laser technology have increased repetition rates and average power for chirped‐pulse laser systems, which offer a promising solution for many applications including energetic proton sources. An important challenge is the need to optimize and control the proton source by varying some of the many degrees of freedom ...
John J. Felice +7 more
wiley +1 more source
Hygroscopic Organic Complex Mutated Helmholtz Plane of Zn Anode for Outstanding Zinc Ion Battery
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Simple and commercial approach was established to in‐situ construct a hygroscopic Zn complex protective layer. This protective layer can absorb water molecules and trap it away from Zn anode. The hygroscopic layer can dehydrate the electrolyte and enhance the de‐solvation process and partial form nitrogen rich SEI which lead to reduce the mechanical ...
Abdelnaby M. Elshahawy +5 more
wiley +1 more source