Results 191 to 200 of about 6,270,767 (256)

The Ubiquitin Ligase Zinc Finger SWIM Domain-Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA-7 Axis. [PDF]

Glia
Lei J, Zhong S, Fan R, Shu X, Wang G, Guo J, Xue S, Zheng L, Ren A, Ji J, Yang B, Duan S, Wang Z, Guo X.   +13 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ФоÑмÑÐ²Ð°Ð½Ð½Ñ ÑиклÑÑÐ½Ð¸Ñ Ð°Ð»Ð³Ð¾ÑиÑмÑв багаÑопаÑамеÑÑиÑного аналÑÐ·Ñ Ð¿ÑоÑеÑÑв ÑÑнкÑÑонÑÐ²Ð°Ð½Ð½Ñ Ð¼ÐµÑежÑ

, 2010
Н. Ю.; Национальный авиационный университет Шевченко
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Post-Acute Sequelae Patients with Severe COVID-19 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [PDF]

Eur J Immunol
Ruhl L, Pink I, Chichelnitskiy E, Drick N, Sauer A, Boblitz L, Beushausen K, Keil J, Ullrich AL, Schmidt J, Hoeper MM, Welte T, Kühne JF, Falk CS.   +13 more
europepmc   +1 more source

ÐаÑоби гаÑмонÑзаÑÑÑ Ð½Ð°Ð²ÑалÑÐ½Ð¸Ñ Ð¿ÑимÑÑÐµÐ½Ñ Ð² аÑпекÑÑ ÐµÐºÐ¾-виÑованнÑ

, 2016
M. Artenenko, O. Chepeljuk
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses. [PDF]

PLoS Biol
Mulloy RP, Evseev D, Sharlin N, Bui-Marinos MP, Lacasse É, Dubuc I, Flamand L, Corcoran JA.   +7 more
europepmc   +1 more source

ÐÑÑледование ÑоÑиалÑного довеÑÐ¸Ñ Ð² межлиÑноÑÑнÑÑ Ð¾ÑноÑениÑÑ (на пÑимеÑе ÑÑÑденÑеÑÐºÐ¸Ñ Ð³ÑÑпп)

, 2018
Кристина Писарева
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source