Results 51 to 60 of about 6,270,767 (256)

N-(2-Acetamido-2-deoxy-β-d-glucopyranosyl)-N-(3-azidopropyl)-O-methylhydroxylamine

Acta Crystallographica Section E: Crystallographic Communications, 2016
The structure of the title compound, C12H23N5O6, solved using adequate data from a thin crystal plate, confirmed that this useful glycoconjugate was obtained in the ring-closed β-pyranose configuration with 4C1 conformation.
Stefan Munneke, Bridget L. Stocker, Mattie S. M. Timmer, Graeme J. Gainsford   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Erratum to: Supermembranes and domain walls in N $$ \mathcal{N} $$ = 1, D = 4 SYM

Journal of High Energy Physics, 2020
In subsection 6.3 of the paper it has not been taken into account that the domain wall solutions for |k| = N found therein do not satisfy the non-negativity of the contribution to the domain wall tension of the energy density of the scalar field s(x).
Igor Bandos, Stefano Lanza, Dmitri Sorokin   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dynamical symmetry enhancement near N $$ \mathcal{N} $$ = 2, D = 4 gauged supergravity horizons

Journal of High Energy Physics, 2017
We show that all smooth Killing horizons with compact horizon sections of 4-dimensional gauged N $$ \mathcal{N} $$ = 2 supergravity coupled to any number of vector multiplets preserve 2 c 1 K + 4 ℓ $$ 2{c}_1\left(\mathcal{K}\right)+4\ell ...
J. Gutowski, T. Mohaupt, G. Papadopoulos
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

DİE n u t z u n g s m ö g l i c h k e i t e n v o n d e n GEOGRAPHISCHENINFORMATIONSSYSTEMEN BEI DER INYENTUR DER WALDFLÂCHEN

Forestist, 1996
M it dieser A rbeit İst die N utzungsm öglichkeiten von den geographischen Inform ationssystem en bei der Inventur der W aldflâchen untersucht.
Ayhan KOÇ, Ahmet Yeşil
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Minimal D = 4 N $$ \mathcal{N} $$ = 2 supergravity from D = 11: an M-theory free lunch

Journal of High Energy Physics, 2019
We present a new consistent truncation of D = 11 supergravity to D = 4 N $$ \mathcal{N} $$ = 2 minimal gauged supergravity, on the seven-dimensional internal Riemannian space corresponding to the most general class of D = 11 solutions with an AdS4 factor
Gabriel Larios, Oscar Varela
doaj   +1 more source