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Results 141 to 150 of about 5,873,563 (251)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source

Diverse biofilm-forming <i>Sphingomonadaceae</i> represent twelve novel species isolated from glaciers on the Tibetan Plateau. [PDF]

Int J Syst Evol Microbiol
Han D, Xin YH, Liu Q.
europepmc +1 more source

, 2014
Orynkul Esimova, Gulmira Isenova
openalex +1 more source

, 2020
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openalex

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source

Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel Hydrazinecarbothioamides. [PDF]

Turk J Pharm Sci
Dincel ED +5 more
europepmc +1 more source

, 2015
Бруно Николовски +4 more
openalex

, 2020
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openalex

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source

Beyond the surface of capacity building: a mixed-methods study of the core functions and forms of dissemination and implementation science consultations. [PDF]

Implement Sci Commun
Swanson KN +12 more
europepmc +1 more source

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