Results 151 to 160 of about 6,154,682 (249)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Systematic Evaluation of a Mouse Model of Aging-Associated Parkinson's Disease Induced with MPTP and D-Galactose. [PDF]

Biology (Basel)
Liu T, Liu X, Chen Q, Ren J, Li Z, Qiu X, Wang X, Wu L, Hu M, Chen D, Zhang H, Geng X.   +11 more
europepmc   +1 more source

ЦелеÑообÑазноÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑазной Ñепной ÑеакÑии (PCR) Ñ ÑиÑÑÑгиÑеÑÐºÐ¸Ñ Ð¿Ð°ÑиенÑов Ñ Ð¸Ð½ÑекÑионнÑм ÑндокаÑдиÑом

, 2015
L.А. Maltseva, А.Б. Кутовой, Н Ф Мосенцев   +2 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Vitamin D Deficiency as a Risk Factor for Onset and Recurrence of Sudden Sensorineural Hearing Loss: A Prospective Cohort Study With Age-Specific Analysis. [PDF]

Food Sci Nutr
Hui Q, Xiang T, Qinglan X, Shuowei Y, Mengshi C, Qin X, Hongyin L, Juntao Y, Yunping F.   +8 more
europepmc   +1 more source

СÑÑаÑÐ½Ñ Ð°ÑпекÑи ÑÑÑÑÑгÑÑного лÑкÑÐ²Ð°Ð½Ð½Ñ Ð¾ÑÑб поÑилого вÑкÑ, ÑвоÑÐ¸Ñ Ð½Ð° генеÑалÑзований паÑодонÑиÑ

, 2014
Р. С. Турчин, В. П. Пюрик, Г. Б. Проць   +2 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Taserwest neɣ tafeltira deg umezgun n Ǧamal Benɛuf : Bu Tfuset akked Aneggaru ad yerr tawwurt d imedyaten.

Ussnan
Ǧamal Benɛuf d yiwet seg tgejda n umezgun n teqbaylit, ladɣa s tsuqilin d tserwestin i yexdem i tmiga n yimura igraɣlanen yettwasnen, am tmezgunin n Johann Wolfgang von Gothé akked Tawfiq Lḥakim.
Chabha Ben Matouk
doaj  

Impact of vitamin D non-reimbursement policy on therapy discontinuation in the general and rheumatic population in the Netherlands: a cross-sectional study. [PDF]

BMJ Open
Singh A, Huiskes VJB, van den Bemt BJF, van Ameijden H, Nurmohamed MT, Spijkers KM, Vervloet M, Brabers AEM.   +7 more
europepmc   +1 more source

ФÑзÑоÑеÑапевÑиÑÐ½Ñ Ð¼ÐµÑоди лÑкÑÐ²Ð°Ð½Ð½Ñ Ñ Ð¿Ð°ÑодонÑологÑÑ

, 2014
С. І. Бойцанюк, М. А. Лучинський, В. В. Сопотніцька   +2 more
openalex   +2 more sources