Results 111 to 120 of about 5,871,720 (248)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples. [PDF]

Rapid Commun Mass Spectrom
McIntosh OM, Baczynski AA, Matney M, McLain HL, Farnsworth KK, Dworkin JP, Glavin DP, Elsila JE, Xie H, Freeman KH.   +9 more
europepmc   +1 more source

ÐŸÐµÑ€Ñ Ð¿ÐµÐºÑ‚Ð¸Ð²Ð¸ и проблеми на обучението по приложна етика в Ð£Ð½Ð¸Ð²ÐµÑ€Ñ Ð¸Ñ‚ÐµÑ‚Ð° за национално и Ñ Ð²ÐµÑ‚Ð¾Ð²Ð½Ð¾ Ñ Ñ‚Ð¾Ð¿Ð°Ð½Ñ Ñ‚Ð²Ð¾ [PDF]

, 2020
ВаРÐμÐ ⁄ Ñ‚Ð ̧Ð ⁄ а ДраР⁄ аРР̧ÐμРа
openalex  

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Superior health-related physical fitness and well-being in 12-15-year-old Danish adolescents who are active in organized leisure-time sports - a cross-sectional study. [PDF]

PLoS One
Meiner CB, Eckert C, Aggestrup CS, Pfeffer K, Tarantino G, Prisak C, Cimenti C, Thøgersen-Ntoumani C, Ntoumanis N, Krustrup P, Larsen MN.   +10 more
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

D. Seifried, N. Stark: Energiedienstleistungen - Rezension

Technikfolgenabschätzung – Theorie und Praxis, 1994
Torsten Fleischer
doaj   +1 more source

Patient and provider perspective with the use of a central intake system (CIS) for surgical waitlist management: a systematic review. [PDF]

BMJ Open
Kennedy L, Asante BO, Clement F.
europepmc   +1 more source

Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]

, 2020
Ð Ð ⁄ Ñ‚Ð ⁄ Ð ⁄ ГÐμруР⁄ Ð ⁄ Ð
openalex  

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source