Results 41 to 50 of about 5,871,720 (248)
Supermembranes and domain walls in N $$ \mathcal{N} $$ = 1, D = 4 SYM
Journal of High Energy Physics, 2019 We construct a manifestly supersymmetric and kappa-symmetry invariant worldvolume action describing the coupling of a dynamical membrane to an N $$ \mathcal{N} $$ = 1, D = 4 SU(N ) super-Yang-Mills multiplet.
Igor Bandos +2 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Pofessor D. J. van Rooy- 'n waardering
Koers : Bulletin for Christian Scholarship, 1956 So ken ons vir Dirk Jan van Rooy. Deur sy wysheid is hy ’n toring van krag in elke kring waarin hy hom beweeg.
W. P. Robbertse
doaj +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
N-[4-(β-d-Allopyranosyloxy)benzylidene]methylamine
Acta Crystallographica Section E, 2009 The title compound, C14H19NO6, was synthesized by the condensation reaction between hecilid (4-formylphenl-β-d-allopyranoside) and methylamine in methanol.
Shu-Fan Yin +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
(n,p), (n,2n), (n,d), and (n,α) cross-section calculations of 16O with 0-40 MeV energy neutrons
EPJ Web of Conferences, 2015 Oxygen is one of the elements which interacts with emitted neutrons after fission reactions. Oxygen exists abundantly both in nuclear fuel (UO2) and moderators (H2O).
Ozdemir Omer Faruk, Arasoglu Ali
doaj +1 more source
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Pediatric Neurology Briefs, 2013 Investigators at Universities of Barcelona, Pennsylvania, Oviedo, and Valencia, and the Spanish NMDAR Encephalitis Work Group report the clinical features of 20 pediatric patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis seen in a ...
J Gordon Millichap
doaj +1 more source