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Results 71 to 80 of about 5,873,848 (258)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source

, 2019
This paper begins with the understanding of art museums as privileged spaces of enunciation and, therefore, their importance for the visibility for producers and artworks.
Petroni, Ilze
core

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source

ÐÐšÐžÐÐžÐœÐ˜Ð§Ð•Ð¡ÐšÐ˜Ð• Ð Ð«Ð§ÐÐ“Ð˜ ÐœÐ£ÐÐ˜Ð¦Ð˜ÐŸÐÐ›Ð¬ÐÐžÐ™ ÐŸÐžÐ›Ð˜Ð¢Ð˜ÐšÐ˜ Ð’ Ð¡Ð¤Ð•Ð Ð• ÐžÐ¥Ð ÐÐÐ« ÐÐ¢ÐœÐžÐ¡Ð¤Ð•Ð ÐÐžÐ“Ðž Ð’ÐžÐ—Ð”Ð£Ð¥Ð ÐÐ ÐŸÐ Ð˜ÐœÐ•Ð Ð• Ð“ÐžÐ ÐžÐ”Ð Ð›Ð¬Ð’ÐžÐ’Ð

, 2019
The central proposal of this research project is to analyze the dynamics that occurred in the process of manumission, during the nineteenth century, in the Province of Cartagena. Basically, what we are trying to explain are the means that enslaved blacks
Guzmán García, Jonathan
core

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source

ÐžÐ¡ÐžÐ‘Ð•ÐÐÐžÐ¡Ð¢Ð˜ Ð ÐÐ¡Ð§Ð•Ð¢Ð Ð¡Ð¢ÐžÐ˜ÐœÐžÐ¡Ð¢Ð˜ Ð—Ð•ÐœÐ•Ð›Ð¬ÐÐžÐ“Ðž Ð£Ð§ÐÐ¡Ð¢ÐšÐ Ð”Ð›Ð¯ Ð¡Ð¢Ð ÐžÐ˜Ð¢Ð•Ð›Ð¬Ð¡Ð¢Ð’Ð Ð˜ ÐžÐ‘Ð¡Ð›Ð£Ð–Ð˜Ð’ÐÐÐ˜Ð¯ Ð–Ð˜Ð›ÐžÐ“Ðž Ð”ÐžÐœÐ .

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source

Ticraḍ, gar usemres d wazal n yizamulen i d-mmalent

Ussnan
This contribution aims to describe the practice of tattooing in some Amazigh regions. It tries to list the different techniques, the actors plus the means used to succeed in this practice which has a high value in the society.
Ourida AISSOU
doaj

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computer science
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medicine
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combinatorics
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