Results 141 to 150 of about 386 (165)

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin   +8 more
wiley   +1 more source

A New Three‐Dimensional Microstructure‐Resolved Model to Assess Mechanical Stress in Solid‐State Battery Electrodes

open access: yesBatteries &Supercaps, EarlyView.
Electrochemical–mechanical coupling in a 3D‐resolved microstructure of a solid‐state battery electrode. In all‐solid‐state batteries (ASSBs), the mechanical stress generated during electrode (de)lithiation plays a critical role in determining the cell longevity because of the induced degradation mechanisms.
Siwar Ben Hadj Ali   +4 more
wiley   +1 more source

Analyzing the Impact of Electrolyte Motion Induced Salt Inhomogeneity Effect on Apparent Aging: Role of Current Rates and Temperature Effects in Accelerated Cyclic Aging Tests in Li‐Ion Batteries

open access: yesBatteries &Supercaps, EarlyView.
Lithium‐ion batteries subjected to accelerated cycling can display recoverable capacity loss unrelated to real lifetime. This study explains the origin through loss of homogeneity of lithium distribution in the anode and salt concentration in the electrolyte.
Pablo Morales Torricos   +5 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

open access: yesBMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang   +9 more
wiley   +1 more source

Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske   +5 more
wiley   +1 more source

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