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Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
A Model-based Repository for Open Source Service and Component Integration. [PDF]
Open source is a software development paradigm that has seen a huge rise in recent years. It reduces IT costs and time to market, while increasing security and reliability.
Cuadrado Latasa, Felix +3 more
core
Paradoxical time and providential history in Shakespeare and Bacon [PDF]
Few of Shakespeare's tragic characters have had so many detractors as Richard II, who has been variously dismissed as a capricious tyrant, a self-absorbed poet, and a Protean dramatic force whose unpredictable actions at times threaten the structural ...
Rodríguez García, José María
core +3 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A simple approach to distributed objects in prolog
We present the design of a distributed object system for Prolog, based on adding remote execution and distribution capabilities to a previously existing object system. Remote execution brings RPC into a Prolog system, and its semantics is easy to express
Carro Liñares, Manuel +1 more
core
A theoretical model for the combustion of droplets in supercritical conditions and gas pockets [PDF]
Supercritical combustion of droplets is studied by means of a physical model which assumes spherical symmetry, laminar conditions, constant pressure and a zero-thickness flame.
Crespo Martínez, Antonio +2 more
core
On the pulsating instability of two-dimensional flames [PDF]
We consider a well-known thermo-diffusive model for the propagation of a premixed, adiabatic flame front in the large-activation-energy limit. That model depends only on one nondimensional parameter β, the reduced Lewis number.
Carlos Alvarez Pereira +6 more
core +2 more sources
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Constructs and evaluation strategies for intelligent speculative parallelism - armageddon revisited [PDF]
This report addresses speculative parallelism (the assignment of spare processing resources to tasks which are not known to be strictly required for the successful completion of a computation) at the user and application level.
Guzman, Adolfo, Hermenegildo, Manuel V.
core +1 more source

