Results 21 to 30 of about 97,960 (198)

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Low‐Threshold Red Lasing in Diketopyrrolopyrrole‐Based Organic Semiconductor Films

Angewandte Chemie International Edition, EarlyView.
Low‐threshold organic semiconductor lasers (OSLs) in the red region are achieved using diketopyrrolopyrrole (DPP) derivatives (DPA‐DPPMe and HMAT‐d‐DPP). Molecular design enables precise control of radiative‐decay and molecular orientation, suppressing optical losses and enhancing gain.
Youhei Chitose, Ryota Zenke, Takuma Saeki, Hsin‐Yi Wei, Rahul Murali, Shota Fukuma, Yusei Kaya, Gomathi Vinayakam Mageswari, Sai Santosh Kumar Raavi, Ja‐Hon Lin, Tzu‐Chau Lin, Chihaya Adachi   +11 more
wiley   +1 more source

Analysis of regulatory review models and approval timelines across selected African medicines regulatory authorities using the OpERA framework (2020–2024)

British Journal of Clinical Pharmacology, EarlyView.
Background The World Health Organization (WHO) developed the Global Benchmarking Tool (GBT) to assess national regulatory systems and support regulatory‐system strengthening across regulatory functions. Several African National Medicines Regulatory Authorities (NMRAs) have achieved Maturity Level 3 (ML3).
Constance Sakala Chisha, Stephanie Leigh, Makomani Siyanga, Grace Matimba, Richard Rukwata, Mercy Owusu‐Asante, Kwabena Frimpong‐Manso Opuni, Pratibha Sobrun, Boitumelo Semete‐Makokotlela, Adem Kermad, Stuart Walker   +10 more
wiley   +1 more source

AI‐Enhanced Laser Manufacturing: A Social Life Cycle Perspective From the White Goods Industry

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainable manufacturing transitions require companies to demonstrate not only environmental and economic benefits, but also measurable advances in corporate social responsibility (CSR). Therefore, we propose using a guideline‐based Social Life Cycle Assessment (S‐LCA) aligned with UNEP (2020) and ISO 14075 (2024) to evaluate the social ...
Ricardo Mejía‐Marchena, José Osorio‐Tejada, Farshid Sadeghi‐Khanegah, Abdullah Sert, Volker Hessel   +4 more
wiley   +1 more source

Toward a Sustainability Standard for Cultural Organizations: Borrowing From Tourism

Sustainable Development, EarlyView.
ABSTRACT Cultural organizations are increasingly engaging with sustainability, yet they lack a sector‐specific standard to guide and institutionalize efforts as long‐term strategies. This study reviews research papers on sustainability standards in the tourism sector, a field with greater experience with such tools, and horizontally borrows insights ...
Małgorzata Ćwikła, Leticia Labaronne
wiley   +1 more source

Los Manríquez y su empresa criminal Las Mudanzas. Prestigio y consumo de familias que circulan mercancía caliente en el centro de México

Economic Anthropology, EarlyView.
RESUMEN A partir del estudio de caso de una familia de tres generaciones dedicada al robo y a la circulación de mercancía caliente en el centro de México, analizo las formas en que sus integrantes cultivan su idea de prestigio y cómo esta se relaciona con sus motivaciones.
Marco Antonio Zagal Guzmán
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Teaching for Wonder: Pedagogical Openings for Epistemic Change in the Climate Crisis

British Journal of Management, EarlyView.
Abstract The accelerating climate crisis demands profound changes in how management learning and education prepares students to engage with uncertainty and ecological interdependence. While recent scholarship calls for epistemic transformation in business schools, there is limited understanding of how pedagogy might cultivate the orientations required ...
Chloe Preece, Pilar Rojas‐Gaviria, Emma Surman   +2 more
wiley   +1 more source

There Is no First Phase of the Jespersen Cycle1

Transactions of the Philological Society, EarlyView.
Abstract This paper challenges the traditional conception of the Jespersen Cycle by arguing that no ‘pure’ first phase of the cycle exists where a single negator operates without reinforcement. Drawing on historical data from Northern Italian dialects (Piedmontese, Lombard, Emilian), we demonstrate that emphatic negative structures systematically co ...
Tommaso Mattiuzzi, Cecilia Poletto
wiley   +1 more source

Intellectual Property Restitution

The Modern Law Review, EarlyView.
In Europe, open GLAM movements and cultural restitution reforms are overlooking a crucial aspect that should not be underestimated: what should happen to the archival materials, digital collections and intellectual property that are indelibly linked to cultural property.
Andrea Wallace, Mathilde Pavis
wiley   +1 more source