Results 21 to 30 of about 18,577,748 (232)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Ciência e Agrotecnologia, 2012 In recent decades, studies on human nutrition have emphasized the importance of omega-3 and 6 intake. Since flaxseed is a good source for such fatty acids, the aim of this study was to develop a Brazilian cheese roll enriched with flaxseed flour.
Alessandra Costa +3 more
doaj +1 more source
Efeitos do ômega-3 nas doenças cardiovasculares: uma revisão [PDF]
, 2012 Monografia apresentada ao setor de Pós-Graduação da Universidade do Extremo Sul Catarinense – UNESC, para a obtenção do titulo de especialista em Nutrição Clinica.Os ácidos graxos são cadeia de carbono, usualmente de 12 a 24, que apresentam um radical ...
Napoli, Lilian Brunato
core
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Ácidos graxos poli-insaturados ômega-3 e lúpus eritematoso sistêmico: o que sabemos?
Revista Brasileira de Reumatologia, 2014 Diversos estudos têm demonstrado a habilidade dos ácidos graxos ômega-3 em reduzir asconcentrações de proteína C-reativa (PCR), eicosanoides pró-inflamatórios, citocinas, quimiocinas e de outros biomarcadores da inflamação.
Mariane Curado Borges +4 more
doaj +1 more source
O açaí como fonte de ácidos graxos Ômega-9, Ômega-6 e Ômega-3. [PDF]
, 2017 O açaí é considerado um alimento energético e benéfico à saúde, sendo fonte de fibras, de proteínas, de vitamina E e de ácidos graxos essenciais, como Ômega-6 e Ômega- 9, além de minerais, como manganês, boro, cromo e cobre.
FREITAS-SILVA, O. +3 more
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SUPLEMENTAÇÃO COM ÔMEGA 3 E ROTULAGEM: UMA REVISÃO
, 2023 Omega-3 is the group of fatty acids of a polyunsaturated nature that has numerous health functions, found mainly in the intake of foods such as seafood, fish, and even seaweed.
GIOVANNA NUNES MOURA
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source