Results 61 to 70 of about 4,388,618 (289)

Pojetí demokratického právního státu v rozhodnutí ÚS

open access: yesČasopis pro Právní Vědu a Praxi, 1994
Návrh skupiny 41 poslanců PČR na zrušení zákona č. 198/1994 Sb. o protipránosti komunistického režimu a odporu proti němu byl ÚS zamítnut jednomyslně, což - alespoň formálně - zvyšuje autoritu jeho rozhodnutí.
František Šamalík
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Comparative analysis of a hybrid KNN–SVM model versus individual ML techniques for solar power forecasting in Bangladesh

open access: yesHybrid Advances
Proper power system operation in areas that have a high degree of climatic variability including Bangladesh requires proper solar power forecasting. This paper analyzes a cascade hybrid KNN–SVM model to predict solar power per hour and their performance ...
Md.Mushfiq Us Salehin
doaj   +1 more source

Pràctiques de laboratori de Genètica: Grau en Biotecnologia [PDF]

open access: yes, 2011
Es realitzaran dues pràctiques, una sobre la "Segregació de caràcters", en què es farà ús de la Drosophila melanogaster com a organisme experimental, i una altra sobre "Cromosomes politènics", en què es farà ús de la Drosophila subobscura.
Ferré Manzanero, Juan
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Judikatura ESLP k trestání sexuálního násilí: Dobré úmysly, špatné právo?

open access: yesČasopis pro Právní Vědu a Praxi
Článek kriticky diskutuje závěry dvou nedávných významných rozsudků Evropského soudu pro lidská práva (věci M.G. proti Litvě a Vučković proti Chorvatsku), které se týkají trestání sexuálního násilí.
Jakub Drápal
doaj   +1 more source

Residència universitària al barri del Carme a Reus [PDF]

open access: yes, 2016
Rehabilitació d'una antiga fàbrica esclofolladora d'avellanes i nous, per adaptar-la al nou ús de residència d'estudiants al barri del Carme de ...
Ponce Salvadó, Daniel
core  

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