Results 201 to 210 of about 212,783 (242)

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

open access: yesCell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong   +9 more
wiley   +1 more source

Perspectives on Pertussis Prevention

open access: yes
Acta Paediatrica, EarlyView.
Ulrich Heininger
wiley   +1 more source

Born to run? Associations between gestational and early‐life exposures and later‐life performance outcomes in Thoroughbreds

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Gestational and early‐life exposures may modulate development during growth and influence future athletic performance. Objectives To investigate associations between gestational and early‐life exposures in Thoroughbreds and (i) likelihood of racing, (ii) total number of runs and (iii) total prizemoney by the end of the 3‐year‐old ...
Rebecca Mouncey   +3 more
wiley   +1 more source

Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

open access: yesHIV Medicine, EarlyView.
Abstract Introduction Integrase strand transfer inhibitors (INSTIs) are first‐line antiretroviral medications used in pregnancy. Pre‐clinical research suggests adverse effects in human stem cells associated with second‐ versus first‐generation INSTIs.
Rosa Balleny   +12 more
wiley   +1 more source

Annual Research Review: Early conduct problems – precursors, outcomes, and etiology

open access: yesJournal of Child Psychology and Psychiatry, EarlyView.
During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist ...
Luke W. Hyde   +2 more
wiley   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

open access: yesJournal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson   +4 more
wiley   +1 more source

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