Results 201 to 210 of about 416,352 (291)

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

ÜNİVERSİTE ÖĞRENCİLERİNİN AYRIŞMA-BİREYLEŞME DÜZEYLERİNİN BAZI DEĞİŞKENLERE GÖRE İNCELENMESİ

, 2010
Mehmet Güven, Sevda Aslan
openalex   +1 more source

Salvage therapy with JAK inhibitors in refractory Takayasu arteritis: a multicentre experience. [PDF]

RMD Open
Mekinian A, Meneses S, Biard L, Dagna L, Novikov P, Salvarani C, Espitia O, Hernández-Rodríguez J, Sacre K, Lioger B, Dufrost V, Audemard-Verger A, Tomelleri A, Kuwana M, Mukuchyan V, Dellal A, Muratore F, Campochiaro C, Moiseev S, Cacoub P, Fain O, Saadoun D, French Takayasu network.   +22 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Squamous cell carcinoma arising in mature ovarian teratoma: a rare clinical entity. [PDF]

Oxf Med Case Reports
Hamdaoui Y, Chetibi A, El Achouri I, Kharkhach A, Ali HA, Bouhout T, Serji B.   +6 more
europepmc   +1 more source

Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser

Advanced Science, EarlyView.
An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu, Aswathy Sundaresan, Nazire‐Begüm Kazkal, Clement Lafargue, Lior Zarfaty, Li‐Gang Wang, Ofek Birnholtz, Dominique Decanini, Melanie Lebental, Patrick Sebbah   +9 more
wiley   +1 more source

SOSYAL MEDYANIN KULLANIM AMAÇLARI: ÜNİVERSİTE ÇALIŞANLARI ÖRNEĞİ

, 2017
Buket Buluk Eşitti, Bekir Eşitti, Mustafa Boz   +2 more
openalex   +2 more sources

Correction: Basket trials in rare diseases: a systematic review of current practices, methodological challenges, and future directions. [PDF]

Orphanet J Rare Dis
Khazen W, Corriol-Rohou S, Evangelista T, Valent A, Abbas S, Nissan X, Mejat A.   +6 more
europepmc   +1 more source

Dilute but Dense – Reversible Crosslinking Enables Water‐Rich (Bio)polymer Condensates

Advanced Science, EarlyView.
Reversible crosslinking between two types of (bio)polymers drives liquid–liquid phase separation even in good solvent. The arrangement of binding motifs controls condensate formation and density, and internal network structure. Simulations and theory reveal a closed‐loop coexistence phase diagram at very low monomer concentrations and re‐entrant ...
Xinxiang Chen, Jude Ann Vishnu, Pol Besenius, Julian König, Friederike Schmid   +4 more
wiley   +1 more source