Results 111 to 120 of about 1,298,122 (296)

Do We Have the Spark? [PDF]

open access: yesZdr Varst, 2022
Rupel VP, Marušič D.
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Rationalization of Piston-rod Production [PDF]

open access: yes, 2018
Bakalářská práce se zabývá racionalizací technologie soustružení táhel. V úvodní části práce je popsán stávající stav technologie výroby včetně technologického postupu, použitých nástrojů a zařízení používaný ve výrobním provozu v Pustějově. Hlavní náplň
Klein, Jiří
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

SPÔSOBY REPREZENTÁCIE RIEŠENIA ÚLOHY KOORDINÁCIE CESTOVNÝCH PORIADKOV GENETICKÝMI ALGORITMAMI

open access: yesPerner’s Contacts, 2009
Článok je zameraný na spôsoby reprezentácie úlohy zostavovania a optimalizácie cestovných poriadkov pre mestskú hromadnú dopravu v rámci prestupného uzla.
Gabriel Fedorko   +2 more
doaj  

Computer Game Based on Artificial Inteligence [PDF]

open access: yes, 2010
Bakalářská práce se zabývá problematikou umělé inteligence v počítačové hře. V práci je uveden návrh dvourozměrné počítačové hry pro dva hráče, kde jednoho z nich může řídit počítač.
Serédi, Silvester
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

An Interactive Simulator for Data-flow Graphs [PDF]

open access: yes, 2015
Grafy toku dat jsou často používány při návrhu hardware. Jsou však vhodné také pro provádění hlubších analýz návrhů (např. funkční a formální verifikace).
Kovařík, David
core  

Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

open access: yesCell, 2015
Bernd Zetsche   +11 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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