Results 211 to 220 of about 1,298,122 (296)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Biology of CRISPR-Cas: Backward and Forward.

Cell, 2018
Frank Hille, Hagen Richter, Shi Pey Wong, Majda Bratovič, Sarah Ressel, E. Charpentier   +5 more
semanticscholar   +1 more source

The Results of the "My Challenge" Camp in Addressing Childhood Obesity. [PDF]

Zdr Varst
Poklar Vatovec T, Jakus T, Pucer P, Prunk Franetič B, Stubelj M.   +4 more
europepmc   +1 more source

Psychometric Properties of the Slovak Version of Short Dark Triad. [PDF]

Eur J Investig Health Psychol Educ, 2021
Čopková R, Šafár L.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Diversity and evolution of class 2 CRISPR–Cas systems

Nature Reviews Microbiology, 2017
Sergey A. Shmakov, A. Smargon, David A. Scott, David B. T. Cox, N. Pyzocha, Winston X. Yan, Omar O. Abudayyeh, J. Gootenberg, K. Makarova, Y. Wolf, K. Severinov, Feng Zhang, E. Koonin   +12 more
semanticscholar   +1 more source

Prognostic Role of HER2 Status and Adjuvant Trastuzumab Treatment in Lymph Node-Negative Breast Cancer Patients - a Retrospective Single Center Analysis. [PDF]

Breast Care (Basel), 2016
Fokter Dovnik N, Dovnik A, Čas Sikošek N, Ravnik M, Arko D, Takač I.   +5 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Integrative taxonomy reveals cryptic diversity within the <i>Euphorbia nicaeensis</i> alliance (Euphorbiaceae) in the central Balkan Peninsula. [PDF]

Front Plant Sci
Sharovikj Ivanova A, Schönswetter P, Kostadinovski M, Barfuss MHJ, Ćušterevska R, Frajman B.   +5 more
europepmc   +1 more source