Results 151 to 160 of about 12,801 (176)

Fucoxanthin Ameliorates MASLD by Directly Targeting GRP78 to Restore ER Homeostasis and Activate AMPK Signaling

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Proposed model of fucoxanthin in ameliorating MASLD via the GRP78‐AMPK axis. In MASLD, excessive lipid accumulation (FFA, TG, DNL) leads to ER stress activation (upregulation of CHOP, ATF6, IRE1) and GRP78 dysfunction, promoting hepatic lipid droplet (LD) formation. Fucoxanthin directly binds to GRP78, which in turn activates AMPK signaling.
Lin Zhang   +9 more
wiley   +1 more source

Shifting Towards Empagliflozin First‐Line Therapy in Glycogen Storage Disease Type Ib: A Nationwide Real‐World Study

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Neutrophil dysfunction and neutropenia are burdensome findings in glycogen storage disease type Ib (GSDIb). Treatment with granulocyte‐colony stimulating factor (G‐CSF) often corrects neutropenia but fails to improve clinical symptoms like inflammatory bowel disease (IBD).
Sema Kalkan Uçar   +32 more
wiley   +1 more source

In the Era of mpMRI and PSMA PET/CT: Does Digital Rectal Examination Still Matter?

open access: yesThe Prostate, Volume 86, Issue 7, Page 805-810, May 15, 2026.
ABSTRACT Background With the increasing integration of multiparametric MRI (mpMRI) and 68Ga‐PSMA PET/CT into the diagnostic and staging algorithms of prostate cancer (PCa), digital rectal examination (DRE)—a once foundational and cost‐effective physical examination—has gradually become marginalized in daily clinical practice.
Anil Eker   +10 more
wiley   +1 more source

Investigation of the Seroprevalence of Lentivirus ovivismae and Lentivirus capartenc (Formerly Known as Maedi‐Visna and Caprine Arthritis‐Encephalitis Virus) Infections in Sheep and Goats in the Yozgat Region

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study conducted in the Yozgat region determined a prevalence of 6.35% for maedi‐visna in sheep and 17.5% for caprine arthritis encephalitis in goats, providing critical data for small ruminant health and disease management in the area. ABSTRACT Background Lentivirus ovivismae and Lentivirus capartenc (formerly maedi‐visna and caprine arthritis ...
Emre Sayar   +3 more
wiley   +1 more source

Association of Milk C‐Reactive Protein With Subclinical Mastitis in Dairy Buffaloes

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Milk C‐reactive protein (CRP) concentrations were significantly increased in subclinical mastitis‐positive mammary lobe samples from dairy buffaloes and were consistent with somatic cell count and bacteriological findings, indicating that milk CRP reflects mammary inflammatory activity.
Ahmet Sabuncu   +7 more
wiley   +1 more source

Serum Proteomic Analysis Using Gel‐Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non‐Malignant Conditions

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study establishes a GeLC‐MS/MS‐based serum proteomics workflow for canine oral oncology to differentiate malignancies from non‐malignant conditions. Comprehensive protein profiling, pathway analysis and protein–drug interaction mapping reveal candidate biomarkers and insights into the pathogenesis of canine oral cancers.
Sekkarin Ploypetch   +4 more
wiley   +1 more source

A Sustainable and Alternative Packaging Approach for EU PDO Erzincan Tulum Cheese Affecting Food Safety, Proteolysis, Lipolysis, and Volatilome in Cheese: Sausage Casing

open access: yesJournal of Food Science, Volume 91, Issue 5, May 2026.
ABSTRACT Erzincan Tulum cheese is highly appreciated by consumers and holds significant social, economic, and cultural importance in Türkiye. Its shelf life and quality are influenced by packaging type and ripening conditions. This study aimed to investigate the effects of three different packaging materials—vacuum packaging (VP); plastic barrels (PBs),
Abdurrahman Çelik   +3 more
wiley   +1 more source

Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
This study shows that long‐term, but not short‐term, stress exposure triggers molecular changes in yeast that mirror established hallmarks of aging, including altered proteostasis, epigenetic shifts, and reduced lifespan. These changes are reversible upon stress removal, and the genes involved are conserved across all domains of life. ABSTRACT Aging is
Yanzhuo Kong   +7 more
wiley   +1 more source

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