Results 11 to 20 of about 2,136 (159)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Contemporary state and possibilities of improvement of local infrastructures for leisure-time physical activity from the aspect of national policy, planning, building, financing and management - the Impala project, part ii.

Tělesná Kultura, 2013
BACKGROUND: The second part of the IMPALA project was based on a wide discussion dealing with the problem of improving the local infrastructure for leisure time physical activity (LTPA) from practical and specific points of view that were represented by ...
Filip Neuls, Michal Kudláček, Jana Vašíčková, Zdeněk Hamřík   +3 more
doaj   +1 more source

Sports training in volleyball youth sport centers in the Czech republic

Tělesná Kultura, 2012
BACKGROUND: Together with the increase of importance of sport as a social phenomenon importance of optimizing the system of sports training of talented athletes is growing.
Michal Lehnert, František Chmelík, Rudolf Psotta, Stanislav Horák   +3 more
doaj   +1 more source

Attractiveness of Czech winegrowing and wine-production in the stage of adaptation to the united market of the European Union

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2006
The paper focuses on the viniculture sector in the Czech Republic in the stage of its adaptation to the united EU-market. The period before the entrance of the Czech Republic to the EU can be characterized by an effort to develop the necessary resources ...
Pavel Tomšík, Pavel Žufan, Jiří Sedlo   +2 more
doaj   +1 more source

The influence of educational attainment and age on the amount and type of physical activity of inhabitants in Pilsen region

Tělesná Kultura, 2012
BACKGROUND: Frequent participation in physical activity (PA) of any kind is an important part of the behavior of each individual and leads to maintaining health and preventing diseases of civilization.
Jana Vašíčková, Petr Valach, Jaromír Votík, František Chmelík   +3 more
doaj   +1 more source

The comparison of school and daily physical activity of 9-10 year old girls and boys

Tělesná Kultura, 2015
BACKGROUND: A preference of sedentary leisure time and an inappropriate environment for physical activity (PA) are some of the main reasons for the decline of PA, decreasing level of physical fitness and an unfavorable balance between energy intake and ...
Romana Šnoblová, Lukáš Jakubec, Sigmund Erik, Dagmar Sigmundová   +3 more
doaj   +1 more source

Physical activity and sport preferences of West Bohemian adolescents

Tělesná Kultura, 2017
Background: Regular physical activity is the crucial factor in treating lifestyle diseases. The age of adolescence is considered as the important period of person's life for creation and further maintaining healthy lifestyle habits.
Petr Valach, Karel Frömel, Lukáš Jakubec, Daniela Benešová, Václav Salcman   +4 more
doaj   +1 more source

Temporal and dynamic characteristics of walking in preschool children with different level of balance: A pilot study

Tělesná Kultura, 2015
BACKGROUND: Developmental coordination disorder (DCD) is impairment in motor coordination which can be manifested also by poor balance. Some childrenwith DCD can be more dependent on visual feedback to control their movements.
Michaela Kubisová, Zdeněk Svoboda, Rudolf Psotta, Miroslav Janura   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The relationship between physical activity and sedentary behaviour in parents and their children aged 9-12

Tělesná Kultura, 2015
BACKGROUND: It is documented that parents have an essential influence on the physical activity (PA) of their children. More physically active parents bring up more physically active children in comparison with children of less physically active parents ...
Sigmund Erik, Dagmar Sigmundová, Petr Baďura, Jaroslava Voráčová   +3 more
doaj   +1 more source