Results 191 to 200 of about 21,037 (220)

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal   +24 more
wiley   +1 more source

Rapid Gamete Maturation and Social Modulation Shape Reproductive Dynamics in a Brood Parasitic Catfish

open access: yesEcology and Evolution, Volume 16, Issue 2, February 2026.
Obligatory brood parasitism in the Lake Tanganyika cuckoo catfish requires rapid reproductive readiness to exploit unpredictable host spawning. Our experiments showed that males are almost continuously ready to reproduce, while females ovulate about once a week, with social interactions enhancing gamete maturation in both sexes.
Holger Zimmermann   +5 more
wiley   +1 more source

All‐Fiber Microsensor of Polarization at Single‐Photon Level Aided by Deep Learning

open access: yesLaser &Photonics Reviews, Volume 20, Issue 3, 5 February 2026.
Introducing a polarization sensor using scattering in a short optical fiber and deep learning. The breakthrough lies in sparse sampling of the scattered light and single‐photon sensitivity. The all‐fiber sensor achieves unprecedented accuracy, speed, resolution, and stability.
Martin Bielak   +2 more
wiley   +1 more source

Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
Hyaluronan degradation in Bacteroides cannot be reliably predicted from canonical PL8/GH88 enzymes alone. Experimental validation reveals coordinated induction of noncanonical accessory proteins (BT4410/BT4411), highlighting pathway plasticity and context‐dependent glycosaminoglycan utilization. ABSTRACT The ability of gut microbes to degrade host‐ and
Martin Sindelar   +6 more
wiley   +1 more source

Beyond contacts: The important role of the support region in protein complex assembly

open access: yesProtein Science, Volume 35, Issue 2, February 2026.
Abstract Protein–protein interactions (PPIs) are fundamental to nearly all cellular processes; however, elucidating the principles governing protein association into complexes remains a significant challenge. Previous studies have shown that protein–protein interfaces can be partitioned into distinct regions—core, rim, and support—that differ in ...
Tom Miclot, Stepan Timr
wiley   +1 more source

Is UWLS Really Better for Medical Research?

open access: yesStatistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT This study evaluates the performance of the Unrestricted Weighted Least Squares (UWLS) estimator in meta‐analyses of medical research. Using a large‐scale simulation approach, it addresses the limitations of model selection criteria in small‐sample contexts.
Sanghyun Hong, W. Robert Reed
wiley   +1 more source

Comparison of ultrasound with computed tomography and whole‐body diffusion‐weighted MRI in prediction of surgical outcome using ESMO‐ESGO criteria in patients with tubo‐ovarian carcinoma: prospective ISAAC study

open access: yesUltrasound in Obstetrics &Gynecology, Volume 67, Issue 2, Page 207-219, February 2026.
ABSTRACT Objective To test the non‐inferiority of extended abdominopelvic ultrasound examination compared with contrast‐enhanced computed tomography (CT) and whole‐body diffusion‐weighted magnetic resonance imaging (WB‐DWI/MRI) in discriminating preoperatively between resectable and non‐resectable disease based on the European Society for Medical ...
D. Fischerova   +26 more
wiley   +1 more source

Contrasting drought responses in two grassland plant–microbe systems under climate change

open access: yesJournal of Ecology, Volume 114, Issue 2, February 2026.
By contrasting two plant strategies across a soil‐moisture gradient under warming and elevated CO2, this study shows how drought and climate jointly shape plant performance and associated microbiomes. The stress‐tolerant Festuca rubra responds through trait plasticity and flexible bacterial communities, whereas the competitive Lolium perenne relies ...
Gang Yang   +4 more
wiley   +1 more source

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