Results 171 to 180 of about 7,637 (185)

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

open access: yesChemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur   +2 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

open access: yesThe FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs   +7 more
wiley   +1 more source

Shaping future forests: how can ecophysiology support climate‐smart forest management?

open access: yesNew Phytologist, Volume 250, Issue 5, Page 2778-2813, June 2026.
Summary Climate change, particularly the associated increase in extreme events and disturbances, threatens the numerous environmental, social, and economic benefits that forests provide, both locally and globally. Heat and drought pose significant risks to forest ecosystems; the anticipated future climate is expected to exacerbate this trend ...
Arthur Gessler   +18 more
wiley   +1 more source

Factors Associated With Suicide History and Parameters of Suicidal Ideation: A Preliminary Investigation of Cognitive Reactivity and Ego Depletion

open access: yesSuicide and Life-Threatening Behavior, Volume 56, Issue 3, June 2026.
ABSTRACT Objectives Understanding suicide risk remains a global health challenge, yet one under‐researched avenue involves examining internalized cognitions related to suicide. This study examined cognitive reactivity and ego depletion in relation to participants' suicide history and the frequency, duration, and intensity of suicidal ideation.
Yawen Zheng   +3 more
wiley   +1 more source

ERKEN DÖNEM ŞİA'SI NASIL MEZHEBE DÖNÜŞTÜ?

open access: yesİstem, 2011
Marshall G. S. Hodgson, Sıddık Korkmaz
doaj  

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