Results 11 to 20 of about 739 (122)
Effect of Slit3 on kidney fibrosis in diabetic kidney disease rats [PDF]
ObjectiveTo explore the effect of slit guidance ligand 3 （Slit3） on rats with diabetic kidney disease （DKD）-induced fibrosis.MethodsA DKD rat model was established by multiple low-dose injections of streptozotocin combined with high-sugar high-fat diet ...
Dong Yang +5 more
core +1 more source
A study on communication mechanism of lung cancer cells in tumor microenvironment mediated by pleckstrin-2/miR-196a signal axis [PDF]
Background and purpose: It is still a great challenge to clarify the signal molecules that mediate the communication between cancer-associated fibroblasts (CAFs) and tumor cells. These signal molecules are very important for cancer metastasis.
WANG Manli, CHEN Hui, DUAN Zhi, XU Qimei, LI Zhen
core +1 more source
Lead-induced transformation of mouse aortic endothelial cells into mesenchymal cells [PDF]
Objective To investigate the effects of lead on the viability, morphology, and function of mouse aortic endothelial cells, as well as whether it induces endothelial-mesenchymal transition (EndMT). Methods Mouse aortic endothelial cells (MAEC) were
LIU Suhui
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Significance of changes in levels of neutrophil extracellular traps during development of silicosis in mice [PDF]
BackgroundSilicosis is an occupational disease mainly characterized by pulmonary progressive fibrosis induced by the accumulation of free silica (SiO2) in the lungs due to long-term exposure to SiO2 dust.
Hailan HE +7 more
core +1 more source
TGF-β1-induces activation of HSC-T6 and epithelial-mesenchymal transition in rats [PDF]
, 2017 目的：研究转化生长因子-β1(TGF-β1)在大鼠肝星状细胞-T6细胞系(HSC-T6)活化及上皮间质转化(EMT)中的作用及其对TGF-β1/Smads信号通路的影响，揭示肝纤维化的发生与发展的分子病理机制，为肝纤维化的逆转治疗及肝硬化的防治提供新靶点。 方法：体外培养大鼠肝星状细胞-T6细胞系，用四甲基偶氮唑盐(MTT)法筛选TGF-β1对肝星状细胞-T6细胞系的最适作用浓度；用MTT法筛选出的最适作用浓度(10μg/L)的TGF-β1处理肝星状细胞24小时，倒置相差显微镜下观察细胞形态学的改变 ...
王丽惠
core
目的探讨铁皮石斛多糖（DOP）对CCl4 诱导肝纤维化（HF）的影响及其作用机制。方法将56 只雄性SD 大鼠随机分为七组：正常组（NG）、模型组（MG）、秋水仙碱组（CG， 0.1mg/ kg）、扶正化瘀组（FG， 0.45g/kg）、低剂量DOP 组（LDG， 0.05 g/kg）、中剂量DOP 组（MDG， 0.1 g/kg）和高剂量DOP 组（HDG，0.2 g/kg），每组8 只。采用皮下注射40% CCl4 橄榄油混合液制备HF 大鼠模型，每3 d 注射1次，共10周。造模第6周结束后 ...
成家茂 +6 more
core +1 more source
Quercetin regulates phenotypic transformation of vascular smooth muscle cells induced by angiotensin Ⅱ through Nrf2/HO-1 signaling pathway [PDF]
ObjectiveTo investigate the protective effect and mechanism of quercetin (QR) against angiotensin Ⅱ (Ang Ⅱ)-induced injury and phenotypic transformation in vascular smooth muscle cells (VSMCs).
Mamatimin ABDURESHIT, Wei ZHU
core +1 more source
连接蛋白Cx43参与冠状动脉平滑肌细胞的异质性促进冠脉再狭窄
Zhongguo shiyan zhenduanxue, 2014 目的研究猪冠状动脉平滑肌细胞异质性与连接蛋白Cx43关系,进一步阐明连接蛋白Cx43在冠状动脉再狭窄发生中的作用。方法分别培养正常及支架术后猪原代冠状动脉平滑肌细胞,正常组应用血小板源生长因子（PDGF-BB）进行诱导,两组细胞分别进行电子显微镜观察细胞形态及结构变化,采用Western Blotting方法及实时荧光定量PCR测定Cx43、Cx40、α-SMA、S100A4蛋白和mRNA表达;然后诱导组应用Cx43阻断剂进行干预,再次检测上述指标变化。结果正常冠状动脉平滑肌细胞可见:纺锤型 ...
张旭敏 +3 more
doaj
Function of IL-33 in Wound Age Estimation of Skin Wounds in Mice [PDF]
, 2020 Objective To explore the application value of interleukin-33 （IL-33） in wound age estimation in forensic practice by observing the sequential changes of IL-33 after skin wound.
YAO Yi HUANG Jun-jie, JIN Xin,et al.
core +1 more source
Zhongguo shiyan zhenduanxue, 2020 目的探讨曲美他嗪对慢性心力衰竭(CHF)大鼠的心肾保护作用及其机制。方法将24只雄性Wistar大鼠随机分为对照组、模型组和实验组各8只。采用肾上腹主动脉缩窄法建立CHF模型,给予实验组大鼠曲美他嗪10mg/(kg·d)灌胃,给予模型组和对照组大鼠等量的生理盐水灌胃。3组大鼠均灌胃4周。比较3组大鼠的左室舒张末压(LVEDP)、左心室压力最大上升速率(+dp/dtmax)、左心室压力最大下降速率(-dp/dtmax);比较3组大鼠心肌组织在HE染色、肾组织在Masson染色下结构的变化 ...
曾显阁
doaj