The role of HSCs in the regulation of T-cell function and the promotion of hepatocellular carcinoma [PDF]
, 2011 背景和目的肝细胞肝癌在世界范围内是一种常见的恶性肿瘤。在众多的治疗方式中，肝切除治疗是首选，然而这并不能改善大部分患者预后不良的现象。近年来，肝脏移植渐成为一种新的有效治疗手段，而肝源不足大大限制了其发展。越来越多的研究表明肝脏中的基质细胞之一—肝星状细胞与肝细胞肝癌的发生发展密切相关。本实验的研究目的是探讨肝星状细胞的免疫活性对T细胞的影响，和在T细胞功能被抑制后对肝细胞肝癌的促进作用。 实验方法本实验中，我们分离培养原代小鼠肝星状细胞。从细胞凋亡、调节性T细胞等方面研究肝星状细胞的免疫抑制和调节功能。
苏维雪
core
Relationship between the Number of Neutrophils and Myofibroblasts during Diabetic Wound Healing and Wound Age [PDF]
, 2019 Objective To investigate the sequential changes of the number of neutrophils and myofibroblasts during diabetic wound healing, and discuss its application value in wound age estimation.
HUANG Jun-jie, YAO Yi, XIA Chong-Jian，et al.
core +1 more source
Effects of miR-204-3p inhibitor on epithelial-mesenchymal transition and silicosis fibrosis in silicon dioxide-induced alveolar epithelial cells [PDF]
BackgroundThe pathogenesis of silicosis has not been fully elucidated, and microRNAs (miRNA) may be involved in the occurrence and development of silicosis.
Fang CHEN +7 more
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Expressions of TGF-β1 and EⅢA-FN after Rat Skeletal Muscle Contusion and Wound Age Estimation [PDF]
, 2019 Objective To study the expressions of transforming growth factor-β1 （TGF-β1） and EⅢA-fibronectin （EⅢA-FN） at different time points of antemortem injury, antemortem injury postmortem expression and postmortem injury and to explore their application value ...
LIU Ran, GE Lu-zou, ZHANG Hai-dong，et al.
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Zhongguo shiyan zhenduanxue, 2009 目的观察基质金属蛋白酶9（MMP9）和基质金属蛋白酶11（MMP11）在肾细胞癌组织中的表达及其与细胞增殖活性和血管生成的关系。方法应用免疫组织化学染色方法检测32例肾细胞癌组织中MMP9、MMP11、第八因子相关抗原（FⅧRAg）、α-平滑肌肌动蛋白（α-SMA）和增殖细胞核抗原（PCNA）的表达。结果MMP9和MMP11在瘤栓中呈强阳性表达,MMP9与MMP11均与FⅧ、α-SMA及PCNA表达密切相关。结论MMP9与MMP11在肾细胞癌增殖活性和血管生成方面均有重要作用。
王医术 +6 more
doaj
大豆异黄酮对实验性肝纤维化大鼠肝星状细胞活化的影响 [PDF]
, 2010 大豆异黄酮(soybean isoflavones,SI)主要存在于大豆中,具有多种生物学活性,在防治疾病中已得到广泛应用,近年来在肝病防治中的应用也越来越受关注 ...
张永生 +5 more
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PTBP1介导长链非编码RNA RP11-879F14.2发挥抑制心肌纤维化的作用 [PDF]
, 2021 目的研究长链非编码RNA（lncRNA）RP11-879F14.2调控心肌成纤维细胞纤维化表型的作用及机制。方法对心衰患者及健康对照者心肌组织进行Masson染色检测心肌胶原水平。lncRNA表达谱芯片检测心衰患者及健康对照者心肌中lncRNAs的表达变化，实时定量荧光PCR（RT-qPCR）验证RP11-879F14.2在心衰患者心肌中的表达。利用重组RP11-879F14.2腺病毒（rAd-RP11-879F14.2）感染人心房肌成纤维细胞（HAFs），检测纤维化相关基因Col1a1 ...
单志新 +7 more
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Establishment of human hepatic stellate cell line and relevant bionomics research [PDF]
, 2012 背景和目的肝细胞性肝癌(Hepatocellularcarcinoma，HCC)是世界上最常见的五大恶性肿瘤之一，每年约有500，000新发病例；尤其是在亚洲，因为乙型肝炎病毒(hepatitisBvirus，HBV)的感染率高，一些国家HCC发病率非常高，而西方一些国家由于丙型肝炎患者增多，HCC发病率也逐年升高。我国是HCC的高发国家，发病率居世界首位，死亡率位于恶性肿瘤死亡率的第二位。肝星状细胞（HepaticStellateCell，HSC）是肝癌微环境中的主要基质细胞，研究表明 ...
刘建明
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Effects and mechanisms of liraglutide in ameliorating liver fibrosis in NAFLD mice [PDF]
Objective·To investigate the effects of liraglutide on liver fibrosis in mice with non-alcoholic fatty liver disease (NAFLD) and the underlying mechanisms.Methods·Twenty 8-week-old C57BL/6J mice were randomly divided into a normal chow diet group (Chow ...
FANG Yunyun +6 more
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Time-dependent Expression and Distribution of AChE during the Skin Incised Wound Healing in Mice [PDF]
, 2019 Objective To study the time-dependent expression and distribution of acetylcholinesterase （AChE） during skin incised wound healing in mice, and discuss its effect in wound healing as well as the feasibility of using it as a reference index for wound age ...
ZHAO Jian-xin, JIN Xin, HUANG Jun-jie，et al.
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