Results 221 to 230 of about 137,715 (267)

Metric structural human connectomes: Localization and multifractality of eigenmodes. [PDF]

Netw Neurosci
Bobyleva A, Gorsky A, Nechaev S, Valba O, Pospelov N.   +4 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Using Network Analysis to Understand the Associations Between Menopausal Symptoms and Mental Health in Women With Intellectual Disabilities. [PDF]

J Appl Res Intellect Disabil
Corrigan S, McCallion P, McCarron M, de Vries J, Burke É.   +4 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Spatial AI in cancer: mapping immune evasion topology through multi-modal omics and deep learning. [PDF]

Front Oncol
Lang L, Cui Y, Wang H, Xiao Y.
europepmc   +1 more source

Artificial intelligence driven multi-omics framework identifies COL6A3 as a diagnostic biomarker and a putative gene target modulated by Embelin in Colorectal cancer. [PDF]

Front Oncol
Javali PS, Thirumurugan K.
europepmc   +1 more source

Single-cell sequencing uncovers disrupted stromal-macrophage communication as a driver of intrauterine adhesion progression. [PDF]

Commun Biol
Dong E, Zhou Z, Chen T, Zhang B, Yin Y, Wu X, Li X, Zhao J, He Y, Yang J, Liu T, Yang N, Zhu R, Rong L, Tian J, Zhou W, Li T.   +16 more
europepmc   +1 more source

Reliable resting-state EEG connectivity measures reveal brain network destabilization and cognitive decoupling following prolonged extreme working conditions. [PDF]

Cogn Neurodyn
Çelik S, Aydın S.
europepmc   +1 more source