Results 31 to 40 of about 88,228 (240)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

γ-Inverse graph of some mixed graphs

Special Matrices
Let GG be a graph. Then, the inverse graph G−1{G}^{-1} of GG is defined to be a graph that has adjacency matrix similar to the inverse of the adjacency matrix of GG, where the similarity matrix is ±1\pm 1 diagonal matrix. In this article, we introduced a
Boulahmar Wafa, Ghanem Manal, Abudayah Mohammad   +2 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Data‐Driven Distributed Safe Control Design for Multi‐Agent Systems

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents a data‐driven control barrier function (CBF) technique for ensuring safe control of multi‐agent systems (MASs) with uncertain linear dynamics. A data‐driven quadratic programming (QP) optimization is first developed for CBF‐based safe control of single‐agent systems using a nonlinear controller. This approach is then extended to the
Marjan Khaledi, Bahare Kiumarsi
wiley   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

New Spectral Bounds on the Chromatic Number Encompassing all Eigenvalues of the Adjacency Matrix [PDF]

Electronic Journal of Combinatorics, 2012
The purpose of this article is to improve existing lower bounds on the chromatic number chi. Let mu_1,...,mu_n be the eigenvalues of the adjacency matrix sorted in non-increasing order. First, we prove the lower bound chi >= 1 + max_m {sum_{i=1}^m mu_i /
P. Wocjan, C. Elphick
semanticscholar   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Subgrain and Cavity Development during Creep of Al‐3.85%Mg

Advanced Engineering Materials, EarlyView.
Al‐3.85%Mg does form subgrains if crept at very high strains. This fact allows the unification of the creep description in two different alloys such as pure Al and Al–Mg alloys. It is classically considered that the creep mechanisms for type M (e.g., pure Al) and type A alloys (e.g., Al–Mg alloys) are different.
Augusta Isaac, Itziar Serrano‐Munoz, Aleksander Kostka, Martinus Putra Widjaja, Gaspar González‐Doncel, Giovanni Bruno, Ricardo Fernández   +6 more
wiley   +1 more source

Maxima of the A_α-Index of Non-Bipartite C₃-Free Graphs for 1/2 < α < 1

Mathematics
In 2017, Nikiforov defined the Aα-matrix of the graph G as Aα(G)=αD(G)+(1−α)A(G),0≤α≤1, which merges the diagonal degree matrix D(G) and the adjacency matrix A(G). In this paper, we characterize the graphs which attain the maximum Aα-index among triangle-
Haixia Zhang, Yu Lei
doaj   +1 more source