Results 11 to 20 of about 1,349 (139)

Practical and Efficient Synthesis of (E)-α,β-Unsaturated Amides Incorporating α-Aminophosphonates via the Horner–Wadsworth–Emmons Reaction [PDF]

Molecules
An efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed.
Sindy Anahi Perez-Aniceto, Erica Cano-Tapia, Mario Ordoñez, José Luis Viveros-Ceballos, Ivan Romero-Estudillo   +4 more
doaj   +2 more sources

The synthesis of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides by the microwave-assisted Pudovik reaction [PDF]

Beilstein Journal of Organic Chemistry, 2017
A family of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides was synthesized by the microwave-assisted solvent-free addition of dialkyl phosphites and diphenylphosphine oxide, respectively, to imines formed from benzaldehyde derivatives and ...
Erika Bálint, Ádám Tajti, Anna Ádám, István Csontos, Konstantin Karaghiosoff, Mátyás Czugler, Péter Ábrányi-Balogh, György Keglevich   +7 more
doaj   +2 more sources

A Comparative Study of New Fluorescent Anthraquinone and Benzanthrone α-Aminophosphonates: Synthesis, Spectroscopy, Toxicology, X-ray Crystallography, and Microscopy of Opisthorchis felineus [PDF]

Molecules
In this research, we explore the synthesis of and characterize α-aminophosphonates derived from anthraquinone and benzanthrone, focusing on their fluorescence properties and potential applications in confocal laser scanning microscopy (CLSM).
Armands Maļeckis, Marija Cvetinska, Muza Kirjušina, Ligita Mežaraupe, Sanita Kecko, Inese Gavarāne, Vladimir Kiyan, Lyudmila Lider, Veronika Pavlova, Marina Savicka, Sergey Belyakov, Elena Kirilova   +11 more
doaj   +2 more sources

Evaluation of Antibacterial Activity against Nosocomial Pathogens of an Enzymatically Derived α-Aminophosphonates Possessing Coumarin Scaffold. [PDF]

Int J Mol Sci, 2023
The purpose of the present study was to evaluate the synergistic effect of two important pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial activity against selected strains of multidrug-resistant nosocomial pathogenic ...
Kowalczyk P, Koszelewski D, Brodzka A, Kramkowski K, Ostaszewski R.   +4 more
europepmc   +3 more sources

Novel α-Aminophosphonates and α-Aminophosphonic Acids: Synthesis, Molecular Docking and Evaluation of Antifungal Activity against Scedosporium Species [PDF]

Molecules, 2022
The Scedosporium genus is an emerging pathogen with worldwide prevalence and high mortality rates that gives multidrug resistance to antifungals; therefore, pharmacological alternatives must be sought for the treatment of diseases caused by this fungus ...
Anthonny Cordero-Díaz, Efren Robledo-Leal, Eugenio Hernández-Fernández, Emanuel Hernández-Núñez, Mariana Elizondo-Zertuche, Susana T. López-Cortina   +5 more
doaj   +2 more sources

Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pK_a as Highly Accurate ³¹P NMR pH Probes. Application to Subtle pH Gradients Determination in Dictyostelium discoideum Cells [PDF]

Molecules, 2022
In order to discover new 31P NMR markers for probing subtle pH changes (
Caroline Delehedde, Marcel Culcasi, Emilie Ricquebourg, Mathieu Cassien, Didier Siri, Bruno Blaive, Sylvia Pietri, Sophie Thétiot-Laurent   +7 more
doaj   +2 more sources

Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent [PDF]

Nature Communications
Chiral α-aminophosphonate derivatives are recognized as valuable compounds in both medicine and organic chemistry. Biomimetic transamination of α-keto phosphonates represents one of the most efficient strategies for accessing these pharmaceutically ...
Dongchen Cai, Longjie Huang, Zhuochuan Wang, Siqi Liu, Xiao Xiao, Baoguo Zhao   +5 more
doaj   +2 more sources

The Synthesis of α-Aminophosphonates via Enantioselective Organocatalytic Reaction of 1-(N-Acylamino)alkylphosphonium Salts with Dimethyl Phosphite [PDF]

Molecules, 2020
α-Aminophosphonic acids are phosphorus analogues of α-amino acids. Compounds of this type find numerous applications in medicine and crop protection due to their unique biological activities.
Alicja Walęcka-Kurczyk, Krzysztof Walczak, Anna Kuźnik, Sebastian Stecko, Agnieszka Październiok-Holewa   +4 more
doaj   +2 more sources

Ultrafast synthesis of α-aminophosphonates using ternary deep eutectic solvent in water [PDF]

Scientific Reports
A remarkably rapid synthesis of α-aminophosphonate medicinally privileged scaffold is developed using a ternary deep eutectic solvent (TDES) of urea/SnCl2/HCl catalyst.
Najmedin Azizi, Navid Habibnejad, Nasim Nourazar, Mehran Shahiri Haghayegh   +3 more
doaj   +2 more sources

Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. [PDF]

Int J Med Chem, 2011
α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities. These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds.
Rezaei Z, Khabnadideh S, Zomorodian K, Pakshir K, Nadali S, Mohtashami N, Faghih Mirzaei E.   +6 more
europepmc   +4 more sources