Green, one-pot synthesis of α-aminophosphonates catalyzed by ZnI2 at room temperature
Green Processing and Synthesis, 2012 An efficient, green and simple solvent-free method is described for the synthesis of α-aminophosphonates based on one-pot three-component condensation of trimethylphosphite, aldehydes and amines in the presence of zinc iodide.
Karimi-Jaberi Zahed +2 more
doaj +1 more source
Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation [PDF]
, 2015 BACKGROUND: Chondrosarcoma is characterized for its lack of response to conventional cytotoxic chemotherapy, propensity for developing lung metastases, and low rates of survival.
Andreas Leithner +5 more
core +1 more source
Ultrasound-promoted solvent-free synthesis of some new α-aminophosphonates as potential antioxidants
Main Group Metal Chemistry, 2020 Ultrasonic irradiation has been adopted in order to achieve an efficient synthesis of some novel α-aminophosphonates by Pudovik reaction. Major benefits of this method are as follows: eco-friendly, free of catalyst, high yielding, uncomplicated work-up ...
Basha Meson Haji +2 more
doaj +1 more source
Modelling of Lewis-Acid Catalyzed Ring Opening of Oxanorbornenes in the Synthesis of Azaheterocyclic Phosphonates [PDF]
, 2010 Since the discovery of the biological activity of aminophosphonates, research started on the synthesis of more constraint azaheterocyclic phosphonates. We developed a route via an intramolecular Diels-Alder reaction towards α-aminophosphonates 1.
Claeys, Diederica +3 more
core +1 more source
Enantioselective Aza-Reformatsky Reaction with Ketimines [PDF]
, 2019 Here, an enantioselective aza-Reformatsky reaction using acyclic ketimine substrates is presented. Using α-phosphorated ketimines as electrophilic substrates and a simple BINOL-derived ligand, phosphorated analogues of aspartic acid holding chiral ...
Maestro Burzaco, Aitor +3 more
core +1 more source
Theoretical exploration on structures, bonding aspects and molecular docking of α -aminophosphonate ligated copper complexes against SARS-CoV-2 proteases [PDF]
, 2022 Recent years have witnessed a growing interest in the biological activity of metal complexes of α-aminophosphonates. Here for the first time, a detailed DFT study on five α-aminophosphonate ligated mononuclear/dinuclear CuII complexes is reported using ...
Ansari, Azaj +5 more
core +1 more source
Journal of Chemistry, 2013 A convenient and efficient synthetic method for the preparation of some new α-aminophosphonate derivatives via a one-pot three-component system has been achieved using Amberlite IRC-748 as a recyclable catalyst. This method not only provides an excellent
Nellisara D. Shashikumar
doaj +1 more source
Cleavage of the Oxanorbornene Oxygen Bridge with Lewis Acids: Computation and Experiment [PDF]
, 2009 Since the discovery of the biological activity of aminophosphonates, research started on the synthesis of more constraint azaheterocyclic phosphonates. We developed a route via an intramolecular Diels-Alder reaction towards α-aminophosphonates 1. [1] The
Claeys, Diederica +6 more
core +1 more source
How to Track Mechanochemical Reactions in Resonant Acoustic Mixers by in Situ Raman Spectroscopy
Chemistry – A European Journal, Volume 31, Issue 48, August 26, 2025.We define a practical operational window for in situ Raman monitoring in resonant acoustic mixing (RAM), a milling media‐free alternative to ball milling. By optimizing key parameters, including vessel design, filling degree, and acceleration, we establish conditions that enable robust spectral acquisition across various mechanochemical transformations.
Steffi Krause Hinojosa +4 more
wiley +1 more source
Diethyl(benzamido(diisopropoxyphosphoryl)methyl) phosphonate [PDF]
, 2022 Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions.
López Francés, Adrián +3 more
core +2 more sources