Results 51 to 60 of about 1,349 (139)

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

ChemCatChem, Volume 17, Issue 15, August 7, 2025.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell, Cosmina Bohan, Alexandra Pop, Esteban P. Urriolabeitia   +3 more
wiley   +1 more source

In silico ADMET, molecular docking study, and nano Sb2O3-catalyzed microwave-mediated synthesis of new α-aminophosphonates as potential anti-diabetic agents

Main Group Metal Chemistry, 2022
An efficient and greener method is developed for the synthesis of α-aminophosphonates via Kabachnik–Fields reaction in solvent free condition using microwave irradiation technique.
Altaff Shaik Mohammad, Rajeswari Tiruveedula Raja, Subramanyam Chennamsetty   +2 more
doaj   +1 more source

Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction [PDF]

, 2018
α-Aminophosphonates are of significant importance due to their biological activity. The most widely applied synthetic routes towards α-aminophosphonates are the Kabachnik-Fields reaction involving the condensation of amines, oxo compounds and >P(O)H ...
Bálint, Erika, Tajti, Ádám, Tripolszky, Anna   +2 more
core   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction [PDF]

, 2018
Chiral phosphoric acids efficiently catalyze the asymmetric Friedel−Crafts reaction of several indoles with α-iminophosphonates to afford enantioenriched hybrid α-aminophosphonate functionalized indole derivatives.Financial support from the Ministerio
Maestro Burzaco, Aitor, Martínez de Marigorta Izaga, Edorta, Palacios Gambra, Francisco Javier, Vicario Hernando, Javier   +3 more
core   +2 more sources

On the Synthesis of [1,3]Azaphospholo[4,5‐f]quino(xa)lines and 2,3‐Dihydro‐[1,3]azaphospholo[4,5‐f]quino(xa)line 1‐oxides

European Journal of Organic Chemistry, Volume 28, Issue 17, May 21, 2025.
Syntheses of quinoline and quinoxaline derivatives fused with phosphacycles were developed from commercially available quinolin‐6‐amine and quinoxalin‐6‐amine. Abstract Despite their potential in areas such as medicinal chemistry and organic materials, scaffolds in which quinoline and quinoxaline are fused to phosphacycles such as 1,3‐oxaphosphole, 1,3‐
Mohamed Ali Dridi, Mohamed Hasyeoui, Frédéric Lassagne, William Erb, Charline Piroud, Thomas Robert, Stéphane Bach, Ali Samarat, Soufiane Touil, Florence Mongin   +9 more
wiley   +1 more source

Synthesis of Two Novel Homologous Polyphosphoesters Containing Aminophosphonate Units and Cytotoxicity of Some Low-Molecular and Polymeric Aminophosphonate Derivatives

Advances in Materials Science and Engineering, 2018
Two novel polyphosphoesters containing anthracene- and furan-derived aminophosphonate moieties, namely, poly[oxyethylene(aminophosphonate-co-H-phosphonate)]s P-12 and P-13, were synthesized through an addition of poly(oxyethylene H-phosphonate) to 9 ...
Ivanka Kraicheva, Georgi Momekov, Rositsa Mihaylova, Margarita Topashka-Ancheva, Ivelina Tsacheva, Ivanka Stoineva, Elitsa Vodenicharova, Paraskev Nedialkov   +7 more
doaj   +1 more source

Physicochemical Properties of analogs α-Aminophosphonates Drugs Determined via Molecular Dynamics Simulation

Asian Pacific Journal of Cancer Biology, 2019
Objective: Cyclin-dependent kinases (CDKs, play important roles in cell cycle regulation. Since deregulation of cyclins and/or alteration or absence of inhibitors has been associated with many cancers, there is strong interest in CDKs inhibitors that ...
Reihaneh Sabbaghzadeh
doaj   +1 more source

Természetes aminosavak foszfonsav és foszfinsav analogjai = Phosphonic and phosphinic acid analogues of natural amino acids [PDF]

, 2007
Az amino-foszfon-, és foszfinsavak az aminosavak analogonjainak tekinthetők, ezért mind önmagukban, mind peptidláncba építve számos érdekes felhasználási területtel rendelkeznek.
Bakó, Péter, Mártonffyné Jászay, Zsuzsa, Petneházy, Imre   +2 more
core  

Mapping the Landscape of Anti–Breast Cancer Drug Discovery in Saudi Arabia: A Bibliometric Analysis (2019–2023)

Scientifica, Volume 2025, Issue 1, 2025.
Breast cancer, the most prevalent cancer worldwide, poses a significant public health challenge, especially in the advanced stages. According to the Saudi Health Council (2020), breast cancer is also the leading cancer in Saudi Arabia with recent increases in incidence rates.
Azizah M. Malebari, Abdulrahman A. Alghelis, Rashad S. Alzahrani, Anfal S. Aljahdali, Sukhamoy Gorai   +4 more
wiley   +1 more source