Results 101 to 110 of about 918,188 (129)
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Neuropharmacology, 2018
Peptide and protein neurotoxins, such as &agr;‐conotoxins from Cone snails and &agr;‐neurotoxins from snake venoms, are excellent tools to identify distinct nicotinic acetylcholine receptor (nAChR) subtypes.
Jin-Peng Yu +8 more
semanticscholar +1 more source
Peptide and protein neurotoxins, such as &agr;‐conotoxins from Cone snails and &agr;‐neurotoxins from snake venoms, are excellent tools to identify distinct nicotinic acetylcholine receptor (nAChR) subtypes.
Jin-Peng Yu +8 more
semanticscholar +1 more source
Biochemistry, 2023
α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Panpan Qi +8 more
semanticscholar +1 more source
α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Panpan Qi +8 more
semanticscholar +1 more source
Toxicon
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins.
K. Radhakrishna +5 more
semanticscholar +1 more source
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins.
K. Radhakrishna +5 more
semanticscholar +1 more source
International Journal of Biological Macromolecules
α3β4 nicotinic acetylcholine receptor (nAChR) is a potential therapeutic target for the treatment of drug dependence and addiction, lung cancer, overeating and obesity and other disorders.
Jin-Peng Yu +8 more
semanticscholar +1 more source
α3β4 nicotinic acetylcholine receptor (nAChR) is a potential therapeutic target for the treatment of drug dependence and addiction, lung cancer, overeating and obesity and other disorders.
Jin-Peng Yu +8 more
semanticscholar +1 more source
Biochemical Pharmacology
Conusvenoms are composed of peptides that are commonly post-translationally modified, increasing their chemical diversity beyond what is encoded in the genome and enhancing their potency and selectivity. This study describes how PTMs alter an α-conotoxin'
C. M. Ramones +11 more
semanticscholar +1 more source
Conusvenoms are composed of peptides that are commonly post-translationally modified, increasing their chemical diversity beyond what is encoded in the genome and enhancing their potency and selectivity. This study describes how PTMs alter an α-conotoxin'
C. M. Ramones +11 more
semanticscholar +1 more source
Journal of Biological Chemistry
The α-conotoxins (α-Ctxs) are short, disulfide-rich peptides derived from the venom of the Conus marine snails, primarily acting as antagonists of nicotinic acetylcholine receptors (nAChRs).
Han-Shen Tae +3 more
semanticscholar +1 more source
The α-conotoxins (α-Ctxs) are short, disulfide-rich peptides derived from the venom of the Conus marine snails, primarily acting as antagonists of nicotinic acetylcholine receptors (nAChRs).
Han-Shen Tae +3 more
semanticscholar +1 more source
The α3β4 nAChR tissue distribution identified by fluorescent α-conotoxin [D11A]LvIA.
International Journal of Biological Macromoleculesα3β4, a vital subtype of neuronal nicotinic acetylcholine receptors (nAChRs), is widely distributed in the brain, ganglia, and adrenal glands, associated with addiction and neurological diseases.
Chen-Xing Xu +8 more
semanticscholar +1 more source
Neuropharmacology
nAChRs containing α6 subunit (α6* nAChRs) are identified as being involved in Parkinson's disease, dyskinesia, drug addiction, and other disorders. Among these, α6β4 nAChR is recognized as a highly promising target for the development of non-opioid ...
Baixue An +7 more
semanticscholar +1 more source
nAChRs containing α6 subunit (α6* nAChRs) are identified as being involved in Parkinson's disease, dyskinesia, drug addiction, and other disorders. Among these, α6β4 nAChR is recognized as a highly promising target for the development of non-opioid ...
Baixue An +7 more
semanticscholar +1 more source
Marine Drugs
Nicotine is the main substance responsible for the development of tobacco addiction. The α3β4 nicotinic acetylcholine receptors (nAChRs) are a potential key target for mitigating nicotine reward.
Meiting Wang +9 more
semanticscholar +1 more source
Nicotine is the main substance responsible for the development of tobacco addiction. The α3β4 nicotinic acetylcholine receptors (nAChRs) are a potential key target for mitigating nicotine reward.
Meiting Wang +9 more
semanticscholar +1 more source