Results 81 to 90 of about 727,339 (237)
, 2012 Clinical, pharmacological, biochemical, and genetic evidence support the notion that alteration of cholesterol homeostasis strongly predisposes to Alzheimer disease (AD). The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically linked to AD.
Michaki, Vasiliki +5 more
openaire +1 more source
On the convolution product of the distributional families related to the diamond operator
Le Matematiche, 2002 In this paper, we introduce a distributional family K_{α,β} which is related to the Diamond operator ♦^k iterated k-times. At first we study the properties of K_{α,β} and then we give a sense to the convolution product of K_{α,β}∗ K_{α',β'} .
Manuel A. Aguirre Tellez, A. Kananthai
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Results in EngineeringThis study aims to address a central issue in continuous partially accelerated life testing for complete failure data by developing and comparing eight estimating methods for the two-parameter Odd Kappa-Exponential distribution, which features a flexible
Ali A. Al-Shomrani
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Dynamical α-Rényi Entropies of Local Hamiltonians Grow at Most Linearly in Time
Physical Review XWe consider a generic one-dimensional spin system of length L, arbitrarily large, with strictly local interactions, for example, nearest neighbor, and prove that the dynamical α-Rényi entropies ...
Daniele Toniolo, Sougato Bose
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Thermodynamic Product Relations for Generalized Regular Black Hole
Advances in High Energy Physics, 2016 We derive thermodynamic product relations for four-parametric regular black hole (BH) solutions of the Einstein equations coupled with a nonlinear electrodynamics source. The four parameters can be described by the mass (m), charge (q), dipole moment (α),
Parthapratim Pradhan
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Optimal Inequalities for Power Means
Journal of Applied Mathematics, 2012 We present the best possible power mean bounds for the product Mpα(a,b)M-p1-α(a,b) for any p>0, α∈(0,1), and all a,b>0 with a≠b. Here, Mp(a,b) is the pth power mean of two positive numbers a and b.
Yong-Min Li +3 more
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