Results 71 to 80 of about 6,467 (115)

Extracellular binding of indinavir to matrix metalloproteinase-2 and the alpha-7-nicotinic acetylcholine receptor: implications for use in cancer treatment

Heliyon, 2019
Introduction: Results from recent studies have suggested a role for protease inhibitors in altering mechanisms involved in the initiation and proliferation of cancer cells.
Anna Lee, Erin Saito, Sean Ekins, Aaron McMurtray   +3 more
doaj   +1 more source

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

Neural Plasticity, 2015
Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial ...
Lorenzo Di Cesare Mannelli, Barbara Tenci, Matteo Zanardelli, Paola Failli, Carla Ghelardini   +4 more
doaj   +1 more source

Possible neuroimmunomodulation therapy in T-cell-mediated oral diseases

Dental Hypotheses, 2015
Introduction: Recurrent aphthous stomatitis and oral lichen planus are local chronic inflammatory diseases which are implicated in T cell-mediated immunity.
Tsuyoshi Sato, Michihiko Usui, Yuichiro Enoki, Shoichiro Kokabu, Tetsuya Yoda   +4 more
doaj   +1 more source

The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein

Frontiers in Cellular and Infection Microbiology
The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien, Shelly Thao, Lahra Weber, Helen L. Danielson, Agatha D. Boldt, Karsten Hueffer, Maegan M. Weltzin   +6 more
doaj   +1 more source

GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors.

PLoS ONE, 2019
α7 Nicotinic acetylcholine receptors (nAChRs) reportedly reduce inflammation by blocking effects of the important pro-inflammatory transcription factor, nuclear factor kappa-light chain-enhancer of B cells (NFκB).
Brijesh K Garg, Ralph H Loring
doaj   +1 more source

Efecto modulador de los glucocorticoides sobre la angiogénesis mediada por PI3K/Akt activada por α7-nAChR: Una revisión narrativa

ARS Medica
Introducción: los glucocorticoides (GC) han sido ampliamente utilizados en el tratamiento de patologías oculares debido a sus efectos antiinflamatorios y anti-angiogénicos.
Matías Latorre de Halleux, Bastián Hernández Vivanco, Paulina Carvajal Vidal, Magdalena Cortés Saavedra   +3 more
doaj   +1 more source

Stimulation of α7 nAChR leads to regeneration of damaged neurons in adult mammalian retinal disease models. [PDF]

Exp Eye Res, 2021
Webster SE, Sklar NC, Spitsbergen JB, Stanchfield ML, Webster MK, Linn DM, Otteson DC, Linn CL.   +7 more
europepmc   +1 more source

In silico studies of ASEM analogues targeting α7-nAChR and experimental verification. [PDF]

RSC Adv, 2021
Zhou Y, Kuang G, Li J, Halldin C, Nordberg A, Långström B, Tu Y, Ågren H.   +7 more
europepmc   +1 more source

Electroacupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction via Activation of an α7-nAChR Signal in Aged Rats. [PDF]

Neuropsychiatr Dis Treat, 2021
Wang Z, Liu T, Yin C, Li Y, Gao F, Yu L, Wang Q.   +6 more
europepmc   +1 more source

Nicotine regulates autophagy of human periodontal ligament cells through α7 nAchR that promotes secretion of inflammatory factors IL-1β and IL-8. [PDF]

BMC Oral Health, 2021
Du Y, Yang K, Zhou Z, Wu L, Wang L, Chen Y, Ge X, Wang X.   +7 more
europepmc   +1 more source