Results 101 to 110 of about 1,623,110 (217)

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

The effects of low and high glycemic index foods on exercise performance and beta-endorphin responses

Journal of the International Society of Sports Nutrition, 2011
Τhe aim of this study was to examine the effects of the consumption of foods of various glycemic index values on performance, β-endorphin levels and substrate (fat and carbohydrate) utilization during prolonged exercise.
Nikolaidis Michalis G, Fatouros Ioannis, Tofas Trifon, Jamurtas Athanasios Z, Paschalis Vassilis, Yfanti Christina, Raptis Stefanos, Koutedakis Yiannis   +7 more
doaj   +1 more source

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. [PDF]

, 2014
Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia.
A. Cederlund, A. Huutoniemi, Adamantidis, Ahnaou, Aran, B. Agerberth, B. Horvath, Beuckmann, Bittencourt, C. Adori, Chastrette, Conzelmann, Cvetkovic-Lopes, D. Kostyalik, Dauvilliers, David, de Lecea, Diniz Behn, Frisullo, G. Bagdy, Gao, Geis, Gonzalez-Albo, Hallmayer, Han, Hara, Hublin, I. Julkunen, Israeli, Kantor, Kitka, Konadhode, Koo, Kornum, L. Kalmar, Li, Longstreth, M. Partinen, Maulon-Feraille, Mignot, NAHON, Overeem, P. Bergman, Panskepp, Partinen, Peyron, Peyron, Qiu, Rao, Rovere, S. Vas, Sakurai, Saper, Saper, Sasaki, Scammell, T. Hokfelt, T. Sarkanen, Tamamaki, Thannickal, Tsunematsu, van den Pol, Verret, Viale, Watson, Y. Kai-Larsen, Zhang   +66 more
core   +1 more source

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Influences of β-endorphins in Ethanol Consumption Patterns and Acquisition of a Conditioned Taste Aversion Mediated by the Drug

Revista Argentina de Ciencias del Comportamiento, 2009
Rewarding effects of ethanol may be mediated in part by endogenous opioids. Ethanol alters β-endorphin synthesis and release. β-endorphin heterozygous (HT) and knockout (KO) mice consume higher levels of a low-concentrated alcohol solution and show ...
Juan Carlos Molina, Laura M. Vivas, Ximena Caeiro, Paula Abate   +3 more
doaj  

Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde

Frontiers in Behavioral Neuroscience, 2013
Significant evidence implicates the endogenous opioid system (opioid peptides and receptors) in the mechanisms underlying the psychopharmacological effects of ethanol.
Laura eFont, Miguel Ángel eLuján, Raúl ePastor   +2 more
doaj   +1 more source

Aetiology of disturbed milk ejection in parturient primiparous cows [PDF]

, 2017
Milk flow in nine primiparous cows with disturbed milk ejection (D) and in six corresponding control animals (C) with normal milk removal was recorded during machine milking and blood samples were taken before and during milking to determine plasma ...
Blum, Jürg W., Bruckmaier, Rupert M., Schams, Dieter   +2 more
core  

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Electrical Stimulation-Induced Release of β-Endorphin from Genetically Modified Neuro-2a Cells

Cell Transplantation, 2008
The quantity of therapeutic gene products released from genetically engineered cells can be controlled externally at different levels. The widely used approach of controlling expression, however, generally has the disadvantage that chemical substances ...
Volker Storn, Michael Kirschbaum, Burkhard Schlosshauer, Andreas F. Mack, Cornelia Fricke   +4 more
doaj   +1 more source

The Evolutionary Biology of Female‐Biased Pain and Its Disorders

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT This article describes and evaluates a general evolutionary theory for explaining variation among individuals in sensitivity to pain, the Vulnerability‐Value‐Opportunity model. The model posits that pain sensitivity is mediated by vulnerability to fitness‐reducing injury (probabilities of damage, including from infection), Fisherian ...
Bernard Crespi
wiley   +1 more source