Results 161 to 170 of about 3,095,875 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Almost α-γ-Irresolute Functions

Journal of New Results in Science, 2014
functions called almost γ-irresolute functions and almost α-γirresolute functions in topological spaces. We obtain several characterizations of these classes and study their properties and investigate the relationships with the known non-continuous ...
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

β-Lapachone-Induced Oxidative Stress Causes PARP-Dependent NAD⁺-Depletion that Affects the Energy Metabolism of Cultured Primary Rat Astrocytes. [PDF]

Neurochem Res
Willker JE, Dringen R.
europepmc   +1 more source

Aristotle on μετὰ λο?γου capacities and voluntary animal locomotion. Part one: the psychic arguments

Revista Archai
According to the dominant interpretation of the distinction between capacities that are "without-λόγος" (ἄλογοι) and capacities that are "with-λόγος" (μετὰ λόγου, Met., IX 2,1046a34-b2), the latter would be unique to human beings. We can find four arguments in defense of that thesis in the secondary bibliography. This article
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Cytoplasmic region of beta-dystroglycan is essential for postsynaptic maturation and neuromuscular function in mice. [PDF]

Proc Natl Acad Sci U S A
Hord JM, Turk R, Kusano H, Rader EP, Burns S, Gastel Z, Prouty SJ, Yu L, Burden SJ, Campbell KP.   +9 more
europepmc   +1 more source

Dose Aspirin Inhibit the Expression of Nuclear β-CateninIn VivoAs It DoesIn VitroStudies? [PDF]

, 2013
Dong‐Hoon Yang
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Fungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation. [PDF]

Nutrients
Samiksha F, Singh D, Harbool SS, Di Martino L, Kruithoff C, S McCormick T, Ghannoum M.   +6 more
europepmc   +1 more source