Results 31 to 40 of about 24,700 (165)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

The association between βeta 2-microglobulin and bronchopulmonary dysplasia

Türk Biyokimya Dergisi, 2023
Previous studies showed that increased urinary Beta 2-microglobulin (β2-M) level is associated with fetal inflammatory response and successfully predict bronchopulmonary dysplasia (BPD).
Ceran Burak, Kadıoğlu Şimşek Gülsüm, Beşer Esra, Tayman Cüneyt, Canpolat Fuat Emre, Kanmaz Kutman Hayriye Gözde   +5 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Persistent inflammation and endothelial activation in HIV-1 infected patients after 12 years of antiretroviral therapy. [PDF]

PLoS ONE, 2013
The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).Inflammation and endothelial activation were assessed by measuring levels of ...
Frederikke F Rönsholt, Henrik Ullum, Terese L Katzenstein, Jan Gerstoft, Sisse R Ostrowski   +4 more
doaj   +1 more source

Soluble markers of B cell activation suggest a role of B cells in the pathogenesis of systemic sclerosis-associated pulmonary arterial hypertension

Frontiers in Immunology, 2022
IntroductionSoluble markers of B cell activation are interesting diagnostic and prognostic tools in autoimmune diseases. Data in systemic sclerosis (SSc) are scarce and few studies focused on their association with disease characteristics.Methods1. Serum
Sébastien Sanges, Sébastien Sanges, Sébastien Sanges, Sébastien Sanges, Sébastien Sanges, Thomas Guerrier, Thomas Guerrier, Thomas Guerrier, Alain Duhamel, Lucile Guilbert, Lucile Guilbert, Lucile Guilbert, Carine Hauspie, Carine Hauspie, Carine Hauspie, Alexis Largy, Alexis Largy, Maïté Balden, Maïté Balden, Maïté Balden, Céline Podevin, Guillaume Lefèvre, Guillaume Lefèvre, Guillaume Lefèvre, Manel Jendoubi, Manel Jendoubi, Silvia Speca, Silvia Speca, Éric Hachulla, Éric Hachulla, Éric Hachulla, Éric Hachulla, Éric Hachulla, Vincent Sobanski, Vincent Sobanski, Vincent Sobanski, Vincent Sobanski, Vincent Sobanski, Sylvain Dubucquoi, Sylvain Dubucquoi, Sylvain Dubucquoi, David Launay, David Launay, David Launay, David Launay, David Launay   +45 more
doaj   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

Analysis of factors associated with concurrent acute renal tubular injury in idiopathic membranous nephropathy patients

Linchuang shenzangbing zazhi
Objective To explore the influencing factors the combination of acute renal tubular injury （ARTI） in patients with idiopathic membranous nephropathy （IMN） in a multi-ethnic area of Guangxi.
Mei-fang Shang, Yuan Cheng, Dong-li Qi, Sheng-chun Wu, Ling-qiao Wei, Xun Qin, Ji Cen, Qi-jun Wan, Zhe Wei   +8 more
doaj   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Immune Markers in Pregnancy A Study on Neopterin, β2-Microglobulin, Deoxythymidine Kinase and C-Reactive Protein

Pteridines, 1989
Neopterin and β2-microglobulin but neither C-reactive protein nor deoxythymidine kinase increased in maternal serum from pregnancy week 20 to 40. Only maternal C-reactive protein concentrations changed during vaginal delivery and after 4 days post partum.
Norman Margareta, Bremme Katarina, Eneroth Peter   +2 more
doaj   +1 more source