Results 321 to 330 of about 172,175 (356)

Quantitation of Vaporized γ-Aminobutyric Acid in Cigarette Smoke Extract From e-Cigarettes by the Combination of HPLC-Fluorescence Detection and Derivatization With DBD-F. [PDF]

Luminescence
Wada M, Onodera H, Takada M, Saruwatari S, Mutoh J, Tachibana K, Hayama T, Kishikawa N, Kuroda N.   +8 more
europepmc   +1 more source

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo, Fabio Arturo Iannotti, Denise Drongitis, Katiuscia Martinello, Loredana Poeta, Adriano Barra, Gaetano Terrone, Sergio Fucile, Vincenzo Di Marzo, Maria Giuseppina Miano   +9 more
wiley   +1 more source

Optimization of Germination Conditions for Enriched γ-Aminobutyric Acid and Phenolic Compounds of Foxtail Millet Sprouts by Response Surface Methodology. [PDF]

Foods
Yu S, Li C, Wang X, Herrera-Balandrano DD, Johnson JB, Xiang J.   +5 more
europepmc   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, EarlyView.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam. [PDF]

Mol Brain
Kosaki Y, Nishizawa D, Hasegawa J, Yoshida K, Ikeda K, Ichinohe T.   +5 more
europepmc   +1 more source

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Cognitive dysfunction in schizophrenia patients caused by down-regulation of γ-aminobutyric acid receptor subunits. [PDF]

World J Psychiatry
Chen X, Zhou YN, Lu XZ, Li RJ, Xiong YF, Sheng X, Zhu WW.   +6 more
europepmc   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

The Antioxidant and Anti-Fatigue Effects of Rare Ginsenosides and γ-Aminobutyric Acid in Fermented Ginseng and Germinated Brown Rice Puree. [PDF]

Int J Mol Sci
Feng S, Li T, Wei X, Zheng Y, Zhang Y, Li G, Zhao Y.   +6 more
europepmc   +1 more source

Distinct impacts of sodium channel blockers on the strength–duration properties of human motor cortex neurons

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how voltage‐gated sodium channel (VGSC) blockers modulate cortical excitability in vivo. VGSCs are critical for regulating axonal excitability, yet the effects of sodium channel‐blocking medications on human cortical neurons remain poorly characterized.
Lorenzo Rocchi, Kate Brown, Alessandro Di Santo, Hannah Smith, Angel V. Peterchev, John C. Rothwell, Ricci Hannah   +6 more
wiley   +1 more source