Results 41 to 50 of about 5,905,192 (340)

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, Volume 599, Issue 8, Page 1159-1168, April 2025.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Crystal structure of 2-(3-bromophenyl)-1,3-dithiane

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C10H11BrS2, the 1,3-dithiane ring has a chair conformation with the 1,4-disposed C atoms being above and below the remaining four atoms. The bromobenzene ring occupies an equatorial position and forms a dihedral angle of 86.38 (12)°
Julio Zukerman-Schpector, Ignez Caracelli, Hélio A. Stefani, Olga Gozhina, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Unification of Electromagnetic Interactions and Gravitational Interactions [PDF]

Commun.Theor.Phys.38:322-326,2002, 2002
Unified theory of gravitational interactions and electromagnetic interactions is discussed in this paper. Based on gauge principle, electromagnetic interactions and gravitational interactions are formulated in the same manner and are unified in a semi-direct product group of U(1) Abel gauge group and gravitational gauge group.
arxiv   +1 more source

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Journal of the American Chemical Society, 2022
In proteins, the amino acids Phe, Tyr, and especially Trp are frequently involved in π interactions such as π–π, cation−π, and CH−π bonds. These interactions are often crucial for protein structure and protein–ligand binding.
Jinfeng Shao, Bastiaan P Kuiper, A. Thunnissen, R. Cool, Liang Zhou, Chenxi Huang, B. Dijkstra, J. Broos   +7 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A dispersive study of final-state interactions in $$K\rightarrow \pi \pi \pi $$ K → π π π amplitudes

European Physical Journal C: Particles and Fields
A system of dispersive representations of the Omnès–Khuri–Treiman–Sawyer–Wali type for the final-state interactions in the amplitudes of the $$K\rightarrow \pi \pi \pi $$ K → π π π weak transitions is constructed, under the assumptions that CP and ...
Véronique Bernard, Sébastien Descotes-Genon, Marc Knecht, Bachir Moussallam   +3 more
doaj   +1 more source

Crystal structure of 1-methoxypyrene

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C17H12O, crystallized with three independent molecules (A, B and C) in the asymmetric unit. In the crystal, the three independent molecules are linked by π–π interactions [centroid–centroid distances = 3.551 (3)–3.977 (2) Å], which ...
Eric G. Morales-Espinoza, Ernesto Rivera, Reyna Reyes-Martínez, Simón Hernández-Ortega, David Morales-Morales   +4 more
doaj   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Interactiveness Field in Human-Object Interactions [PDF]

arXiv, 2022
Human-Object Interaction (HOI) detection plays a core role in activity understanding. Though recent two/one-stage methods have achieved impressive results, as an essential step, discovering interactive human-object pairs remains challenging. Both one/two-stage methods fail to effectively extract interactive pairs instead of generating redundant ...
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source