Results 51 to 60 of about 5,905,192 (340)

Ethyl 2-[(azidocarbonyl)amino]benzoate

IUCrData, 2016
In the almost planar (r.m.s. deviation = 0.038 Å) title compound, C10H10N4O3, an intramolecular N—H...O interaction closes an S(6) ring. In the crystal, aromatic π–π stacking interactions occur [inter-centroid distance = 3.65 (2) Å].
Hasna Yassine, Abderrafia Hafid, Mostafa Khouili, Olivier Mentre, El Mostafa Ketatni   +4 more
doaj   +1 more source

Structural Achievability of an NH–π Interaction between Gln and Phe in a Crystal Structure of a Collagen-like Peptide

Biomolecules, 2022
NH–π interactions between polar and aromatic residues are well distributed in proteins whose stabilizing effects have been investigated in globular and fibrous proteins.
Ruixue Zhang, You Xu, Jun Lan, Shilong Fan, Jing Huang, Fei Xu   +5 more
doaj   +1 more source

Metal-Metal and π-π Interactions Directed End-to-End Assembly of Gold Nanorods.

Journal of the American Chemical Society, 2016
The end-to-end aggregation of gold nanorods (GNRs) has been demonstrated to be directed by a thioacetate-containing alkynylplatinum(II) terpyridine complex. The in situ deprotected complex is preferentially attached at the ends of the gold nanorods (GNRs)
F. Leung, Sammual Yu-Lut Leung, C. Y. Chung, V. Yam   +3 more
semanticscholar   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

tert-Butyl 2,3-dihydro-1H-cyclopenta[b]indole-4-carboxylate

IUCrData, 2016
In the title molecule, C16H19NO2, all the non-hydrogen atoms except two of the C atoms of the tert-butyl group lie on a crystallographic mirror plane. No classical hydrogen bonds are observed.
Jason A. Jordon, Jeanese C. Badenock, Gordon W. Gribble, Manpreet Kaur, Jerry P. Jasinski   +4 more
doaj   +1 more source

Crystal structure of 1,1′-(pyridine-2,6-diyl)bis[N-(pyridin-2-ylmethyl)methanaminium] dichloride dihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2021
In the title compound, C19H23N52+·2Cl−·2H2O, the two pyridine side arms are not coplanar, with the terminal pyridine rings subtending a dihedral angle of 26.45 (6)°.
Layachi Merabet, Marine Tassé, Sonia Mallet-Ladeira, Lakhemici Kaboub, Isabelle Malfant   +4 more
doaj   +1 more source

Topology of RNA–protein nucleobase–amino acid π–π interactions and comparison to analogous DNA–protein π–π contacts

RNA: A publication of the RNA Society, 2016
The present work analyzed 120 high-resolution X-ray crystal structures and identified 335 RNA–protein π-interactions (154 nonredundant) between a nucleobase and aromatic (W, H, F, or Y) or acyclic (R, E, or D) π-containing amino acid.
K. Wilson, Devany J Holland, S. Wetmore
semanticscholar   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, Volume 19, Issue 5, Page 1404-1421, May 2025.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

4-{(E)-[(2-Hydroxynaphthalen-1-yl)methylidene]amino}-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one: a new polymorph (β-phase)

IUCrData, 2017
The title molecule, C22H19N3O2, is a new polymorphic modification, viz. the β-phase; the α-phase has been previously published [Liang & Wang (2010). Acta Cryst. E66, o1968–o1969].
Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Mustafa R. Albayati, Alaa F. Mohamed   +4 more
doaj   +1 more source