Results 81 to 90 of about 3,146,886 (266)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Crystal structure of 4-benzamido-2-hydroxybenzoic acid

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H11NO4, the dihedral angle between the mean planes of the aromatic rings is 3.96 (12)° and an intramolecular O—H...O hydrogen bond closes an S(6) ring. A short intramolecular C—H...O contact is also seen.
Muhammad Shahid, Muhammad Aziz Choudhary, Arshad Farooq Butt, Muhammad Nawaz Tahir, Muhammad Salim   +4 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Shape-Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular π-π Interactions. [PDF]

Adv Sci (Weinh), 2023
Chen X, Zhang T, Liu H, Zang J, Lv C, Du M, Zhao G.   +6 more
europepmc   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Unveiling the alkyne-π interaction using metal-organic cage compounds

Communications Chemistry
Alkynes play a crucial role in chemical synthesis, bio-imaging, and drug design. Despite their significance, the intermolecular interactions involving alkynes have been largely unexplored.
Junrui Liu, Shujun Ning, Ting Chen, Zi-Ang Nan, Zhe-Ning Chen, Luyao Liu, Zhu Zhuo, Qing Li, Wei Wang, Lu Zhang, You-Gui Huang   +10 more
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Thermodynamics of π-π Interactions of Benzene and Phenol in Water. [PDF]

Int J Mol Sci, 2022
Paik D, Lee H, Kim H, Choi JM.
europepmc   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Shape-Memory Effect Triggered by π-π Interactions in a Flexible Terpyridine Metal-Organic Framework. [PDF]

ACS Mater Lett, 2023
Roztocki K, Gromelska W, Formalik F, Giordana A, Andreo L, Mahmoudi G, Bon V, Kaskel S, Barbour LJ, Janiak A, Priola E.   +10 more
europepmc   +1 more source