Results 41 to 50 of about 454,694 (225)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
(3Z)-3-Benzylidene-1H-benzimidazo[1,2-a]imidazol-2(3H)-one
IUCrData, 2016 In the title compound, C16H11N3O, the molecular conformation is partially determined by an intramolecular C—H...π(ring) interaction. In the crystal, pairwise N—H...N hydrogen bonds form dimers, which associate into stacks through a combination of C—H...O,
Mohammed Rida +3 more
doaj +1 more source
Magnetism of two-dimensional defects in Pd: stacking faults, twin boundaries and surfaces
, 2006 Careful first-principles density functional calculations reveal the importance of hexagonal versus cubic stacking of closed packed planes of Pd as far as local magnetic properties are concerned.
B. Sampedro +5 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
IUCrData, 2018 In the title compound, C37H28BrClN8O, the linked chlorophenyl, pyrazolyl and thiazolyl ringss are almost coplanar, with dihedral angles of 0.6 (3)° between the chlorophenyl and pyrazolyl rings and 5.4 (3)° between the pyrazolyl and thiazolyl rings.
Gamal A. El-Hiti +5 more
doaj +1 more source
A Simultaneous Stacking and Deblending Algorithm for Astronomical Images
, 2010 Stacking analysis is a means of detecting faint sources using a priori position information to estimate an aggregate signal from individually undetected objects. Confusion severely limits the effectiveness of stacking in deep surveys with limited angular
Blanc +21 more
core +1 more source
Stacking non-BPS D-Branes [PDF]
, 2001 We present a candidate supergravity solution for a stacked configuration of stable non-BPS D-branes in Type II string theory compactified on T^4/Z_2.
Bain +26 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Crystal structure of the borabenzene–2,6-lutidine adduct
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C12H14BN, the complete molecule is generated by a crystallographic twofold axis, with two C atoms, the B atom and the N atom lying on the rotation axis.
Lauri Kivijärvi, Matti Haukka
doaj +1 more source
Design, synthesis and SAR studies of novel tacrine derivatives as potent cholinesterase inhibitors
European Journal of Medicinal Chemistry Reports, 2022 A series of tacrine-2-amide derivatives were synthesized and biologically evaluated for their acetylcholinesterase (AChE) inhibition studies. All synthesized compounds showed a good potency less than 100 nM.
Bhushanarao Dogga +6 more
doaj +1 more source