Results 151 to 160 of about 3,121,151 (264)

Molecular Origins of Philicity: How Atomic Interactions Determine Miscibility and Diffusivity. [PDF]

Chemphyschem
Upterworth AL, Steinkopf TE, Sebastiani D.   +2 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

1,4-Digermacyclopenta-1,3-diene: Continuous Cyclic σ*-π Delocalization Enables Aromatic Stabilization in a Heavy-Element 4π System. [PDF]

Angew Chem Int Ed Engl
Uchida D, Yamada H, Mizuhata Y.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Gas-phase reactivity of aromatic carbon-centered σ,σ-type biradicals toward oligonucleotides of differing lengths and comparison of the reactivity of charged phenyl radicals in solution and in the gas phase

, 2012
The biological activity the enediyne antitumor agents was suggested to arise from formation of aromatic carbon-centered σ,σ-type biradicals, which cause irreversible damage to double stranded DNA. Knowledge on the reactivity of aromatic carbon-centered σ,
Widjaja, Fanny
core  

Bayesian Modeling of Polarizable Water: Lessons for Force Field Development. [PDF]

J Chem Theory Comput
Nordman AT, Engblom S, van der Spoel D.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The N-Terminal Domain of LIC12756 Is the Key Determinant of This Protein's Anti-Sigma Activity Toward LIC12757 in Pathogenic <i>Leptospira interrogans</i>. [PDF]

Pathogens
Kędzierska-Mieszkowska S.
europepmc   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Βίος του Μωάμεθ μετά παραρτήματος περί της Ισλαμικής θρησκείας / υπό Ουασιγκτώνος Ιρβινγγος. Μετάφρασις εκ του Αγγλικού Ανδρέου Σ. Φαραού [PDF]

351 σ.; 11,5χ18,5 ...
Irving, Washington, Φαραός, Ανδρέας Σ.   +1 more
core