Results 211 to 220 of about 327,551 (243)

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Analysis of Reasons for Permanent Teeth Extraction in Dental College Teaching Hospital of Mustansiriyah University, Baghdad/Iraq: A Prospective Cross-Sectional Observational Study. [PDF]

Int J Dent
Jumaah FH.
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Cancer Patterns and Barriers to Care Among Socioeconomically Vulnerable Populations in Tripoli: A Descriptive Study from a Local NGO. [PDF]

Diseases
Darwich MJ, Ksair D, Adra Z, Naji RY, Sayed B, Nasr R, Dassouki Z.   +6 more
europepmc   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source

Treatment of acute coronary syndrome by ground and helicopter ambulance services in Poland: a five-year retrospective study. [PDF]

Front Public Health
Leszczyński PK, Wejnarski A, Buźniak W, Ilczak T, Mitura K, Mitura KM, Celiński D, Szajda SD.   +7 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Diagnostic accuracy of ultrasonography for lower extremity arterial disease in patients with diabetes. [PDF]

Medicine (Baltimore)
Zhao J, Zhang H, Zhang Q, Sun L, Kong J, Gao J, Shao C.   +6 more
europepmc   +1 more source

Lattice Distortion‐Driven Metal Exsolution in Perovskite Oxides

Advanced Science, EarlyView.
This study elucidates the mechanism of lattice distortion‐driven exsolution through a combination of computational simulations and experimental approaches. Lattice distortion facilitates the formation of oxygen vacancies and subsequent metal segregation, thereby enhancing the exsolution behavior.
Yo Han Kim, Uchan Jeon, Hyeongwon Jeong, Bo‐Ram Won, Jeong Woo Han, Jae‐ha Myung   +5 more
wiley   +1 more source

Assessment of language development in children with prelingual single-sided deafness. [PDF]

Acta Otorhinolaryngol Ital
Pastuszak D, Obrycka A, Skarzynski H, Skarzynski PH.   +3 more
europepmc   +1 more source