Results 41 to 50 of about 974,832 (231)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
On the Role of Visuals in Multimodal Answers to Medical Questions [PDF]
, 2007 This paper describes two experiments carried out in order to investigate the role of visuals in multimodal answer presentations for a medical question answering system.
Bosma, Wauter +5 more
core +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Frequentist analyses of solar neutrino data (updated including KamLAND and SNO data) [PDF]
, 2001 The solar neutrino data are analyzed in a frequentist framework, using the Crow-Gardner and Feldman-Cousins prescriptions for the construction of confidence regions.
Creminelli, Paolo +2 more
core +2 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Analysis of Characteristics of Peripheral Arterial Ischemia in Premature Babies and Effects of Nitroglycerin Patch Application [PDF]
Child Health Nursing Research, 2020 Purpose The aim of this retrospective study was to analyze the characteristics of peripheral arterial ischemia and tissue necrosis in premature babies, as well as the effects of nitroglycerin.
Jeongeun Kim, Jin Won Lee, Dong Yeon Kim
doaj +1 more source
Sistem Mina Padi Di Desa Manik Rambung Mendukung Ketahanan Pangan Sumatera Utara [PDF]
, 2015 Rice and fish have been an essential part of the life of Indonesian people which produce from rice field. The research was conducted during two years (Dec.2008 to Sept.2010) using a purposive random sampling using three plots in lowland and terrace from ...
Siregar, A. Z. (Ameilia)
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
On the statistical power of Baarda’s outlier test and some alternative
Journal of Geodetic Science, 2017 Baarda’s outlier test is one of the best established theories in geodetic practice. The optimal test statistic of the local model test for a single outlier is known as the normalized residual.
Lehmann R., Voß-Böhme A.
doaj +1 more source
Acta Clinica Croatica, 2020 The objective of our research was to compare the results of human papillomavirus (HPV) typing and occurrence of the most important risk factors for cervical cancer obtained in the towns of northern, central and southern regions of Montenegro, in subjects
Azra Lukač +4 more
doaj +1 more source