THERAPEUTIC EQUIVALENCE OF ORIGINAL CLOPIDOGREL (PLAVIX) AND ITS GENERIC (EGITROMB). RESULTS OF COMPARATIVE RANDOMIZED CROSS-OVER BLIND STUDY [PDF]
Рациональная фармакотерапия в кардиологии, 2016 Aim. To study therapeutic equivalence (efficacy, safety and tolerability) of original clopidogrel (Plavix) and its generic (Egitromb) in patients of high cardiovascular risk. Material and methods.
V. V. Yakusevich +4 more
doaj +4 more sources
Пути обеспечения качества и безопасности генерических лекарственных препаратов [PDF]
Фармакокинетика и Фармакодинамика, 2012 Рассмотрены некоторые аспекты сравнительных фармацевтических и фармакокинетических исследований оригинальных лекарственных препаратов и их воспроизведённых копий.
А. В. Соколов +4 more
doaj +4 more sources
SOME ASPECTS OF EFFECTIVENESS AND SAFETY OF ANTIBACTERIAL DRUGS IN PREGNANCY [PDF]
Acta Biomedica Scientifica, 2012 Analysis of published data on clinical effectiveness and safety of antimicrobial drugs indicates that original and generic antibacterial medicines sometimes significantly differ in the therapeutic equivalence and in the frequency and severity of side ...
D. Y. Zhukova +2 more
doaj +2 more sources
The interchangeability of drugs from line items of pharmaceutical compliance and clinical efficiency and safety [PDF]
Качественная клиническая практика, 2018 Questions of replacement of original medicines with generic are discussed. The sintesation of identical medicine is a complex challenge from the technological point of view.
N. V. Verlan +4 more
doaj +2 more sources
HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia [PDF]
Фармакокинетика и Фармакодинамика, 2013 A simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic
S. N. Kondratenko +4 more
doaj +2 more sources
The problem of choice: original drug or generic? Emphasis on rosuvastatin [PDF]
, 2022 An increase in the life expectancy of the population and the number of polymorbid patients with a combination of two or more diseases in different age categories, including among young people, has led to a significant increase in the cost of medical care
O. A. Polyakova, O. D. Ostroumova
core +2 more sources
Правовое обеспечение граждан Российской Федерации, страдающих редкими (орфанными) заболеваниями, лекарственными препаратами [PDF]
, 2023 Рассмотрен порядок обеспечения граждан Российской Федерации, страдающих редкими (орфанными) заболеваниями, лекарственными препаратами, в том числе и незарегистрированными на территории Российской Федерации, и выявлены существующие проблемы, а также пути ...
Ядута, С. А.
core +1 more source
Эффективность и безопасность отечественного дженерика травопроста в различных режимах терапии первичной открытоугольной глаукомы [PDF]
, 2021 PURPOSE. Comparative study of the efficacy and safety of the reproduced travoprost drug (generic) TravoprostOptic and the original drug (Travatan) in patients with primary open-angle glaucoma receiving mono- or combination therapy.METHODS.
A. A. Antonov +5 more
core +2 more sources
Рациональная фармакотерапия в кардиологии, 2015 Indications for myocardial cytoprotector, trimetazidine, in patients with ischemic heart disease are analyzed and justified according to evidence based medicine.
Zh. M. Sizova
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To develop a protocol for comparison of efficacy and safety of original drugs with generic ones and to apply this protocol for comparison of generic indapamide (Indap) with original indapamide in two presentations: short acting (Arifon) and long ...
N. P. Kutishenko +3 more
doaj +1 more source