Results 131 to 140 of about 510,460 (285)
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source
Категории диалектики : [межвуз. сб. науч. трудов]. [Вып. 5] : Диалектика прогрессивного развития
, 1976 В очередном, пятом, выпуске межвузовского сборника «Категории диалектики» рассмотрено место категории развития в системе базисных категорий диалектики, ее отношение к категориям противоречия, движения (функционирования) и связи.
core
TreeON: Reconstructing 3D Tree Point Clouds from Orthophotos and Heightmaps
Computer Graphics Forum, EarlyView.Abstract We present TreeON, a novel neural‐based framework for reconstructing detailed 3D tree point clouds from sparse top‐down geodata, using only a single orthophoto and its corresponding Digital Surface Model (DSM). Our method introduces a new training supervision strategy that combines both geometric supervision and a differentiable shadow and ...
Angeliki Grammatikaki +4 more
wiley +1 more source
Terrain Synthesis and Authoring based on Iso‐Contours
Computer Graphics Forum, EarlyView.Abstract Digital terrains are central to realistic landscape depiction, yet authoring tools must balance perceptual realism with intuitive artistic control. We propose a compact vector‐based representation that models terrain as nested iso‐contours, inspired by geomorphology and cartography.
B. Huftier +5 more
wiley +1 more source
Changes in the transformative potential of action proposals in Finnish Red Lists from 1986 to 2019
Conservation Biology, EarlyView.Abstract Red lists provide critical knowledge regarding biodiversity decline, especially in Finland, where broad assessments have been made regularly since the 1980s. They deliver information on the threat status of species and ecosystems, propose actions to guide conservation policy, and have the potential to spur transformative change.
Anni Arponen +4 more
wiley +1 more source
Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases
The FEBS Journal, EarlyView.Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek +12 more
wiley +1 more source
A Comprehensive Approach to Post-Conflict Reconstruction: German Experience in Afghanistan
Vestnik RUDN. International Relations, 2016 As a part of a larger research project on complex linkages between security and development implemented by the Center for Security and Development Studies at the Lomonosov Moscow State University, this paper examines the complex dilemmas of pursuing ...
Philip Olegovich Trunov
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Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators
Allergy, EarlyView.
Jaime Bernaola +14 more
wiley +1 more source
Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3
The FEBS Journal, EarlyView.Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova +6 more
wiley +1 more source