A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses [PDF]
Background: Thoroughbred racehorses are subject to non-traumatic distal limb bone fractures that occur during racing and exercise. Susceptibility to fracture may be due to underlying disturbances in bone metabolism which have a genetic cause.
Blott, Sarah C. +8 more
core +4 more sources
Trade-offs between personal immunity and reproduction in the burying beetle, N. vespilloides [PDF]
We know that parental investment and immune investment are costly processes, but it is unclear which trait will be prioritised when both may be required.
Cotter, Sheena C. +3 more
core +2 more sources
Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes [PDF]
This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health,
Abraham, Prakash +10 more
core +1 more source
Clustering in Additive Mixed Models with Approximate Dirichlet Process Mixtures using the EM Algorithm [PDF]
We consider additive mixed models for longitudinal data with a nonlinear time trend. As random effects distribution an approximate Dirichlet process mixture is proposed that is based on the truncated version of the stick breaking presentation of the ...
Heinzl, Felix, Tutz, Gerhard
core +2 more sources
Variational Bayesian Parameter Estimation Techniques for the General Linear Model [PDF]
Variational Bayes (VB), variational maximum likelihood (VML), restricted maximum likelihood (ReML), and maximum likelihood (ML) are cornerstone parametric statistical estimation techniques in the analysis of functional neuroimaging data.
Ostwald, Dirk, Starke, Ludger
core +1 more source
High-dimensional genome-wide association study and misspecified mixed model analysis
We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent gnome-wide association studies.
Jiang, Jiming +4 more
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Maximum Lilkelihood and Restricted Maximum Likelihood Estimation for a Class of Gaussian Markov Random Fields [PDF]
This work describes a Gaussian Markov random field model that includes several previously proposed models, and studies properties of their maximum likelihood (ML) and restricted maximum likelihood (REML) estimators in a special case.
Victor De Oliveira
core
A multi-trait multi-environment QTL mixed model with an application to drought and nitrogen stress trials in maize (Zea mays L.) [PDF]
Despite QTL mapping being a routine procedure in plant breeding, approaches that fully exploit data from multi-trait multi-environment (MTME) trials are limited.
Crossa, J. +4 more
core +2 more sources
Perspectives from agriculture: advances in livestock breeding - implications for aquaculture genetics [PDF]
In this paper we present livestock breeding developments that could be taken into consideration in the genetic improvement of farmed aquaculture species, especially in freshwater fish.
Nguyen, N.H., Ponzoni, R.W.
core
Out of Sample Estimation for Small Areas using Area Level Data
A Fay-Herriot type model with independent area effects is often assumed when small area estimates based on area level data are required. However, under this approach out of sample areas are limited to synthetic estimates.
Chambers, Ray, Saei, Ayoub
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