Results 101 to 110 of about 3,186,450 (234)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan

Scientific Reports
HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in ...
Chien-An Tu, Chien-Feng Kuo, Chun-Ming Lee, Chang-Pan Liu, Hsiang-Kuang Tseng, Tseng-Yu Huang, Chih-Chen Lin, Hsun Chang, Winter Yu-Ning Lee, Fang-Ju Sun, Zu-Yi Sun, Pei-Ching Lian, Ming-Wei Cheng, Alice Ying-Jung Wu   +13 more
doaj   +1 more source

Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy

Respiratory Research, 2017
Background Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation of profibrotic myofibroblasts is a crucial process for fibrotic remodeling in IPF.
Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano   +26 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Evaluating the diagnostic and prognostic utility of serial KL-6 measurements in connective tissue disease patients at risk for interstitial lung disease: correlations with pulmonary function tests and high-resolution computed tomography

BMC Pulmonary Medicine
Background Interstitial lung diseases associated with connective tissue diseases (CTD-ILD) necessitate reliable biomarkers for effective management.
Jorge Álvarez Troncoso, Óscar Porto Fuentes, María Fernández Velilla, Luis Gómez Carrera, Clara Soto Abánades, Elena Martínez Robles, Raquel Sorriguieta Torre, Juan José Ríos Blanco   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Palivizumab for Severe Respiratory Syncytial Virus Infection in Immunocompetent Adults: A Case Series

Infection and Drug Resistance
Jun-Yu Zhong,1 Ting-Kuang Yeh,2,3 Hsien-Po Huang,2,3 Chun-Mei Ho,2 Po-Yu Liu,2,4,5 Yun-Ching Fu6– 8 1Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Division of Infectious Diseases, Department of Internal Medicine,
Zhong JY, Yeh TK, Huang HP, Ho CM, Liu PY, Fu YC   +5 more
doaj  

Association of obstructive sleep apnea syndrome with the signs of non-alcoholic fatty liver disease and calculated glomerular filtration rate in metabolic syndrome

Терапевтический архив, 2010
Aim: to assess a relationship between obstructive sleep apnea syndrome (OSAS) and the signs of non-alcoholic fatty liver disease (NAFLD) in patients with metabolic syndrome (MS). Material and methods.
M M Severova, V V Fomin, M V Lebedeva, Yu D Sorokin, E A Saginova, E G Minakova, M G Gallyamov, N A Mukhin   +7 more
doaj  

Use of sacubitril/valsartan early after CABG

Open Heart
Background Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary ...
Madina Nurzhanova, Aisulu Musagaliyeva, Raushan Zhakypova, Daniya Senkibayeva, Amina Rakisheva   +4 more
doaj   +1 more source